Last reviewed · How we verify
NCT04194515
Gut Microbiota and Bile Acids in Type 2 Diabetes Mellitus
trial testing YH1 in Diabetes Mellitus, Type 2 in 50 participants. Status unknown.
31 December 2021
Quick facts
| Lead sponsor | Chang Gung Memorial Hospital |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 50 |
| Start date | 1 January 2020 |
| Primary completion | 31 December 2021 |
| Estimated completion | 31 December 2021 |
| Sites | 1 location across Taiwan |
Drugs / interventions tested
Conditions studied
- Diabetes Mellitus, Type 2 — all drugs for Diabetes Mellitus, Type 2 →
- Metformin — all drugs for Metformin →
- YH1 — all drugs for YH1 →
Sponsor
Chang Gung Memorial Hospital
Who can join
Adults 20 to 65, male only, with Diabetes Mellitus, Type 2 or Metformin. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The investigators will evaluate the stool microbiota, serum and fecal bile acid composition, and changes in blood glucose and lipid profile before and after one month of metformin or YH1 treatment.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
The Relationship between the Gut Microbiome and Metformin as a Key for Treating Type 2 Diabetes Mellitus.
Lee CB, Chae SU, Jo SJ, Jerng UM, et al · · 2021 · cited 102× · PMID 33808194 · DOI 10.3390/ijms22073566 -
Gut Microbiota and Bile Acids Mediate the Clinical Benefits of YH1 in Male Patients with Type 2 Diabetes Mellitus: A Pilot Observational Study.
Huang YH, Wu YH, Tang HY, Chen ST, et al · · 2022 · cited 4× · PMID 36145605 · DOI 10.3390/pharmaceutics14091857
Verify or expand the search:
- PubMed search for NCT04194515
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Chang Gung Memorial Hospital trials
Trials by the same sponsor.
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- NCT07036978 — Metabolomic and Immune-Microbiome Profiling for Unresectable Pancreatic Cancer · not yet recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04194515 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Chang Gung Memorial Hospital
- Last refreshed: 27 January 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04194515.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing