Who is sponsoring NCT04194138?

NCT04194138 is sponsored by International Spine Study Group Foundation.

What drugs are being tested in NCT04194138?

Interventions in NCT04194138: Index or spine revision surgery for complex adult spinal deformity.

What condition does NCT04194138 study?

NCT04194138 studies Adult Spinal Deformity, Scoliosis, Kyphosis, Sagittal Imbalance.

Is NCT04194138 still recruiting?

NCT04194138 is currently recruiting now. Last updated 17 February 2026.

Last reviewed 2026-02-17 · How we verify

NCT04194138: CADS

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Complex Adult Deformity Surgery (CADS)

Recruiting now Last updated 17 February 2026

What this trial tests

trial testing Index or spine revision surgery for complex adult spinal deformity in Adult Spinal Deformity in 1,500 participants. Currently enrolling.

Timeline

30 July 2018

Primary endpoint
31 December 2028

31 July 2032

Quick facts

Lead sponsor	International Spine Study Group Foundation
Status	Recruiting now
Study type	OBSERVATIONAL
Enrollment	1,500
Start date	30 July 2018
Primary completion	31 December 2028
Estimated completion	31 July 2032
Sites	18 locations across Canada, United States

Drugs / interventions tested

Index or spine revision surgery for complex adult spinal deformity

Conditions studied

Adult Spinal Deformity — all drugs for Adult Spinal Deformity →
Scoliosis — all drugs for Scoliosis →
Kyphosis — all drugs for Kyphosis →
Sagittal Imbalance — all drugs for Sagittal Imbalance →

Sponsor

International Spine Study Group Foundation

Who can join

18 and older, any sex, with Adult Spinal Deformity or Scoliosis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Evaluate surgical treatment outcomes and identify best practice guidelines for complex adult spinal deformity (ASD) patients, including radiographic and clinical outcomes, surgical and postoperative complications, risk factors for and revision surgery rates, and the role of standard work to improve patient outcomes and reduce surgical and postoperative complications.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

How Good Are Surgeons at Achieving Their Preoperative Goal Sagittal Alignment Following Adult Deformity Surgery?
Smith JS, Elias E, Sursal T, Line B, et al · · 2024 · cited 8× · PMID 36821516 · DOI 10.1177/21925682231161304
Adult Cervical Deformity Patients Have Higher Baseline Frailty, Disability, and Comorbidities Compared With Complex Adult Thoracolumbar Deformity Patients: A Comparative Cohort Study of 616 Patients.
Smith JS, Kelly MP, Buell TJ, Ben-Israel D, et al · · 2025 · cited 4× · PMID 37948666 · DOI 10.1177/21925682231214059
When is staging complex adult spinal deformity advantageous? Identifying subsets of patients who benefit from staged interventions.
Passias PG, Tretiakov P, Onafowokan OO, Das A, et al · · 2025 · cited 2× · PMID 39576989 · DOI 10.3171/2024.8.spine24365

Verify or expand the search:

Other trials of Index or spine revision surgery for complex adult spinal deformity

Trials testing the same drug.

NCT04885244 — Prospective Evaluation of Complex Adult Spinal Deformity (CAD) Treated With Minimally Invasive Surgery · recruiting

Other recruiting trials for Adult Spinal Deformity

Currently open trials in the same condition.

NCT07105189 — Feasibility of Wireless Continuous Vital Sign Monitoring and Impact on Patients Undergoing Adult Spinal Surgery in a Gen · NA · recruiting
NCT04885244 — Prospective Evaluation of Complex Adult Spinal Deformity (CAD) Treated With Minimally Invasive Surgery · recruiting
NCT04888104 — Prospective, Multicenter, Case-Control Analysis of the VersaTie Posterior Fixation System to Prevent Proximal Junctional · recruiting

Other International Spine Study Group Foundation trials

Trials by the same sponsor.

NCT04885244 — Prospective Evaluation of Complex Adult Spinal Deformity (CAD) Treated With Minimally Invasive Surgery · recruiting
NCT04912674 — Evaluation of Symphony™ Posterior Cervical System for Surgical Treatment of Adult Cervical Deformity · active not recruiting
NCT04888104 — Prospective, Multicenter, Case-Control Analysis of the VersaTie Posterior Fixation System to Prevent Proximal Junctional · recruiting
NCT04194996 — Radiographic and Clinical Evaluation of Surgical Treatment for Cervical Deformity: A Multi-Center Study 2.0 · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04194138 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by International Spine Study Group Foundation
Last refreshed: 17 February 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04194138.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing