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NCT04193774: EPSO
Optimization of Sampling and Processing of Samples for Molecular Microbial Research on Ocular Surface Samples
NA trial testing Conjunctival swab in Microbiota in 24 participants. Completed in 31 December 2021.
31 December 2021
Quick facts
| Lead sponsor | Universitaire Ziekenhuizen KU Leuven |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | double |
| Primary purpose | diagnostic |
| Enrollment | 24 |
| Start date | 19 August 2019 |
| Primary completion | 31 December 2021 |
| Estimated completion | 31 December 2021 |
| Sites | 1 location across Belgium |
Drugs / interventions tested
- Conjunctival swab
- Oxybuprocaine Hydrochloride 0.4% Eye Drops — full drug profile →
- artificial tears — full drug profile →
Conditions studied
- Microbiota — all drugs for Microbiota →
- Ocular Surface — all drugs for Ocular Surface →
Sponsor
Universitaire Ziekenhuizen KU Leuven — full company profile →
Who can join
18 and older, any sex, with Microbiota or Ocular Surface. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The use of anesthetics and the processing of the retrieved samples are major confounding factors that influence the results of microbiome research.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
The Effect of Topical Anesthetics on 16S Ribosomal Ribonucleic Acid Amplicon Sequencing Results in Ocular Surface Microbiome Research.
Delbeke H, Casteels I, Joossens M. · · 2022 · cited 11× · PMID 35238917 · DOI 10.1167/tvst.11.3.2 -
DNA extraction protocol impacts ocular surface microbiome profile.
Delbeke H, Casteels I, Joossens M. · · 2023 · cited 8× · PMID 37152736 · DOI 10.3389/fmicb.2023.1128917
Verify or expand the search:
- PubMed search for NCT04193774
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Conjunctival swab
Trials testing the same drug.
- NCT04193917 — Confounding Factors in Ocular Surface Microbiome Research · NA · completed
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Currently open trials in the same condition.
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Other Universitaire Ziekenhuizen KU Leuven trials
Trials by the same sponsor.
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- NCT07356505 — Efficacy and Safety of Micra AV2 Transcatheter Pacing System · NA · recruiting
- NCT07286968 — Gastro-Intestinal Digestion and Physiology After Bariatric Surgery · recruiting
- NCT06962137 — Phase II RAINSPOT: Zolbetuximab-Paclitaxel-Ramucirumab for CLDN18.2 Positive Gastro-esophageal Cancer · Phase 2 · recruiting
- NCT07270536 — Accelerated Pacing and Cardiac Filling Pressures During Exercise in Patients With Heart Failure With Preserved Ejection · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04193774 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Universitaire Ziekenhuizen KU Leuven
- Last refreshed: 22 July 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04193774.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing