NCT04191473

Comparison of EMR-P With Conventional EMR

Status unknown NA Last updated 11 June 2020

What this trial tests

NA trial testing EMR-P in Colonic Polyp in 220 participants. Status unknown.

Timeline

1 May 2020

Primary endpoint
1 October 2020

31 December 2020

Quick facts

Lead sponsor	First Affiliated Hospital of Zhejiang University
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	220
Start date	1 May 2020
Primary completion	1 October 2020
Estimated completion	31 December 2020
Sites	7 locations across China

Drugs / interventions tested

• EMR-P
• CEMR

Conditions studied

• Colonic Polyp — all drugs for Colonic Polyp →

Sponsor

First Affiliated Hospital of Zhejiang University

Who can join

18 and older, any sex, with Colonic Polyp. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Colorectal cancer is the third most common cancer in men and the second most common cancer in women.There are about 14 million cases of colonoscopy in the United States every year. In recent years, the incidence of colorectal cancer in China has risen sharply, becoming a serious threat to people's health.For small(≤ 9mm) lesions, endoscopic biopsy forceps and cold snare polypectomy can be used to remove.For larger lesions, especially laterally spreading tumor,endoscopic mucosal resection is a classic method of treatment.With the increasing diameter of the lesion size(\> 20mm),we also need to adopt endoscopic piecemeal mucosal resection or endoscopic submucosal dissection.

As IT, Hook knife, BB, and other devices appear constantly, foreign researchers recently adopted a variation of conventional EMR（CEMR）, namely endoscopic mucosal resection with circumferential precutting(EMR - P).The technology is superior to conventional EMR for 10 to 20 mm polyps.Moreover, preliminary studies suggest that it has good safety and efficacy, and may be a better method for treatment of 10-20mm polyps under colonoscopy.

This clinical trial is being conducted to compare the efficacy and safety of two methods of polypectomy, CEMR and EMR-P, for 10-20mm colorectal polyps.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Endoscopic mucosal resection-precutting <i>vs</i> conventional endoscopic mucosal resection for sessile colorectal polyps sized 10-20 mm.
   Zhang XQ, Sang JZ, Xu L, Mao XL, et al · · 2022 · cited 5× · PMID 36533110 · DOI 10.3748/wjg.v28.i45.6397