NCT04190862 is a Phase 1 clinical trial of E-CEL UVEC in Anal Fistula, sponsored by Weill Medical College of Cornell University.

Who is sponsoring NCT04190862?

NCT04190862 is sponsored by Weill Medical College of Cornell University.

What drugs are being tested in NCT04190862?

Interventions in NCT04190862: E-CEL UVEC.

What condition does NCT04190862 study?

NCT04190862 studies Anal Fistula.

Is NCT04190862 still recruiting?

NCT04190862 is currently recruiting now. Last updated 18 November 2025.

Last reviewed 2025-11-18 · How we verify

NCT04190862

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

E-CEL UVEC as an Adjunct Cell Therapy for Treatment of Anal Fistulas

Recruiting now Phase 1 Last updated 18 November 2025

What this trial tests

Phase 1 trial testing E-CEL UVEC in Anal Fistula in 39 participants. Currently enrolling.

Timeline

22 January 2020

Primary endpoint
30 September 2026

30 June 2032

Quick facts

Lead sponsor	Weill Medical College of Cornell University
Phase	Phase 1
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	non randomized
Design	sequential
Masking	none
Primary purpose	treatment
Enrollment	39
Start date	22 January 2020
Primary completion	30 September 2026
Estimated completion	30 June 2032
Sites	1 location across United States

Drugs / interventions tested

E-CEL UVEC — full drug profile →

Conditions studied

Anal Fistula — all drugs for Anal Fistula →

Sponsor

Weill Medical College of Cornell University

Who can join

18 and older, any sex, with Anal Fistula. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this study is to determine if endothelial cells derived from human umbilical vein are safe for use in conjunction with fistulotomy for the treatment of simple anal fistulas. Endothelial cells are a special kind of cell in the body that line the inside surface of blood vessels. The goal of the study is to evaluate the preliminary safety of human umbilical vein cells in anal fistula healing.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Endothelial Reprogramming in Atherosclerosis.
Zhang L, Wu X, Hong L. · · 2024 · cited 11× · PMID 38671747 · DOI 10.3390/bioengineering11040325
Improving Fat Transplantation Survival and Vascularization with Adenovirus E4+ Endothelial Cell-Assisted Lipotransfer.
Dong X, Premaratne I, Gadjiko M, Berri N, et al · · 2023 · cited 8× · PMID 35640533 · DOI 10.1159/000525274

Verify or expand the search:

Other recruiting trials for Anal Fistula

Currently open trials in the same condition.

NCT07477496 — Recurrence and Anal Fistula Patient Reported Outcomes Trial · recruiting
NCT07081373 — Study on Repeat Liposomal Bupivacaine for Post-Surgery Pain in Anal Fistula Patients. · NA · recruiting
NCT06803550 — Effect of Enhanced Recovery After Surgery for Benign Anorectal Conditions · NA · recruiting
NCT06303752 — Tissue Therapy of Transsphincteric Anal Fistula · Phase 1, PHASE2 · recruiting
NCT05641844 — A Double Blind, Randomized Controlled Study, Evaluating the Safety and Efficacy of RD2 Ver.02 For the Management of Anal · NA · recruiting

Other Weill Medical College of Cornell University trials

Trials by the same sponsor.

NCT07485712 — Center for Research and Education on Aging and Technology Enhancement - CREATE V - Project 2 · NA · not yet recruiting
NCT05811338 — Center for Research and Education on Aging and Technology Enhancement - CREATE V - Project 1 · NA · not yet recruiting
NCT06118983 — Improving TRansitions ANd OutcomeS for Heart FailurE Patients in Home Health CaRe (I-TRANSFER-HF) · NA · recruiting
NCT06818734 — Implementation of a Clinical Decision Support Tool for Postpartum Depression · NA · not yet recruiting
NCT07485725 — Center for Research and Education on Aging and Technology Enhancement - CREATE V - Project 3 · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04190862 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Weill Medical College of Cornell University
Last refreshed: 18 November 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04190862.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing