NCT04188756 (Reserve) is a NA clinical trial of Exercise in Pulmonary Hypertension, sponsored by University of Giessen.

Who is sponsoring NCT04188756?

NCT04188756 is sponsored by University of Giessen.

What drugs are being tested in NCT04188756?

Interventions in NCT04188756: Exercise.

What condition does NCT04188756 study?

NCT04188756 studies Pulmonary Hypertension, Right Heart Failure, Heart Failure, Contractility, RV-arterial Coupling.

Is NCT04188756 still recruiting?

NCT04188756 is currently status unknown. Last updated 9 November 2021.

Last reviewed 2021-11-09 · How we verify

NCT04188756: Reserve

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

RV Systolic and Diastolic Function and Contractile Reserve Under Acute Exercise and in Response to Chronic Exercise-based Rehabilitation

Status unknown NA Last updated 9 November 2021

What this trial tests

NA trial testing Exercise in Pulmonary Hypertension in 84 participants. Status unknown.

Timeline

1 July 2022

Primary endpoint
1 February 2023

1 July 2024

Quick facts

Lead sponsor	University of Giessen
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	84
Start date	1 July 2022
Primary completion	1 February 2023
Estimated completion	1 July 2024
Sites	1 location across Germany

Drugs / interventions tested

Exercise

Conditions studied

Pulmonary Hypertension — all drugs for Pulmonary Hypertension →
Right Heart Failure — all drugs for Right Heart Failure →
Heart Failure — all drugs for Heart Failure →
Contractility — all drugs for Contractility →

Sponsor

University of Giessen

Who can join

Adults 18 to 75, any sex, with Pulmonary Hypertension or Right Heart Failure. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Exercise training in Pulmonary arterial hypertension in the setting of rehabilitation leads to an enormous improvement of functional state and haemodynamics. However the underlying mechanism is still unkown. It is assumed to be relied on Right ventricular contractile reserve, but this has never been proven with goldstandard PV-loop assessment. Our aim is to evaluate the mechanism leading to the increase in functional state and to evaluate the impact of exercise (acute and chronic) on right ventricular performance

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Exercise-based rehabilitation programmes for pulmonary hypertension.
Morris NR, Kermeen FD, Jones AW, Lee JY, et al · · 2023 · cited 29× · PMID 36947725 · DOI 10.1002/14651858.cd011285.pub3
Effects of Different Types of Exercise Training on Pulmonary Arterial Hypertension: A Systematic Review.
Waller L, Krüger K, Conrad K, Weiss A, et al · · 2020 · cited 14× · PMID 32498263 · DOI 10.3390/jcm9061689

Verify or expand the search:

Other trials of Exercise

Trials testing the same drug.

NCT06231069 — Mixed Exercise Training and Novel Multi-Nutrient Supplementation in Young Adults · NA · withdrawn
NCT07007858 — Effects of High-Velocity Passive Stretch on Spasticity, Function, and Muscle Structure in Spastic CP Children · NA · enrolling by invitation
NCT07589725 — Mulligan Mobilization in Lateral Elbow Tendinopathy · NA · not yet recruiting
NCT07524400 — Effects of Physical Exercise Combined With Transcranial Direct Current Stimulation in Parkinson's Disease · NA · recruiting
NCT06627569 — Exercise Effects on the Neurobiology Underlying Stress-related Eating Behaviors in Veterans · NA · not yet recruiting

Other recruiting trials for Pulmonary Hypertension

Currently open trials in the same condition.

NCT07179380 — Efficacy and Safety Study of Treprostinil Palmitil Inhalation Powder (TPIP) in Participants With Pulmonary Hypertension · Phase 3 · recruiting
NCT07073820 — A Study to Learn About the Study Medicine (Called PF-07868489) in People With Pulmonary Arterial Hypertension Who Have P · Phase 2 · recruiting
NCT06351345 — 129 Xenon Imaging in Patients Treated With Sotatercept · Phase 2 · recruiting
NCT07187206 — Safety and Efficacy of FETO in CDH Phase III · Phase 3 · recruiting
NCT07206173 — Londrina Activities of Daily Living Protocol in Pulmonary Hypertension · recruiting

Other University of Giessen trials

Trials by the same sponsor.

NCT07505511 — Visualization of the Effects of Guideline-directed Medical Therapy (GDMT) on Improving Adherence and Quality of Life in · EARLY_PHASE1 · not yet recruiting
NCT07488468 — Quality Improvement Project to Reduce Preoperative Fasting Times Before Elective Procedures · recruiting
NCT06966739 — Multispectral Optoacustic Imaging in Patients With Myositis · completed
NCT06381427 — Perioperative Interdisciplinary, Intersectoral Process Optimization in Heart Failure · NA · recruiting
NCT06291714 — Non-invasive Measurement of the Hypotension Prediction Index for the Reduction of Intraoperative Hypotension · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04188756 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Giessen
Last refreshed: 9 November 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04188756.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing