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NCT04187326: ALPHA

Assessing Visual Processing in High Anxiety

Completed NA Results posted Last updated 4 September 2025
What this trial tests

NA trial testing Facial Microexpression Training in Anxiety in 23 participants. Completed in 15 March 2024.

Timeline
1 March 2021
Primary endpoint
15 March 2024
15 March 2024

Quick facts

Lead sponsorUniversity of Massachusetts, Worcester
PhaseNA
StatusCompleted
Study typeINTERVENTIONAL
Allocationrandomized
Designparallel
Maskingnone
Primary purposetreatment
Enrollment23
Start date1 March 2021
Primary completion15 March 2024
Estimated completion15 March 2024
Sites1 location across United States

Drugs / interventions tested

Conditions studied

Sponsor

University of Massachusetts, Worcester

Who can join

Adults 18 to 30, any sex, with Anxiety. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Tolerability of the Micro Expression Training Task in Individuals With High Anxiety Primary · six or twelve months post-scan visit

Rates of completion of the behavioral task

GroupValue95% CI
6 Month Micro Expression Training Task5
12 Month Micro Expression Training Task6

Sponsor's own description

High trait anxiety, a stable personality trait, is a risk factor for psychiatric disorders. Individuals with high trait anxiety have difficulty differentiating safety from threat, including visual information like emotional faces. This study aims to characterize visual system function in high trait anxiety. A portion of this study involves an intervention. For the intervention portion, a subset of participants will be asked to return for a lab visit upon completing the first portion of the study (multimodal magnetic resonance imaging (MRI) scan). During this follow up visit, participants will complete a computer task that involves looking at faces and identifying emotions. Participants will complete this task either six months or twelve months after their MRI scan visit. Results from this research have the potential to inform novel therapies that target the visual system in individuals at risk for the development of psychiatric disorders.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.

Verify or expand the search:

Other recruiting trials for Anxiety

Currently open trials in the same condition.

Other University of Massachusetts, Worcester trials

Trials by the same sponsor.

Verify against primary sources

Data sources for this page

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04187326.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing