Last reviewed · How we verify
NCT04186429: EETR
Epigenetic Effects on Traumatic Brain Injury Recovery
trial in Traumatic Brain Injury in 401 participants. Completed in 31 August 2024.
31 August 2024
Quick facts
| Lead sponsor | University of Pittsburgh |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 401 |
| Start date | 1 July 2017 |
| Primary completion | 31 August 2024 |
| Estimated completion | 31 August 2024 |
| Sites | 1 location across United States |
Conditions studied
- Traumatic Brain Injury — all drugs for Traumatic Brain Injury →
- Orthopedic Injury — all drugs for Orthopedic Injury →
Sponsor
University of Pittsburgh
Who can join
Adults 3 to 18, any sex, with Traumatic Brain Injury or Orthopedic Injury. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Methylation of the brain-derived neurotrophic factor (BDNF) gene is involved in both the biological encoding of childhood adversity and neuroplasticity following traumatic brain injury (TBI). This research will characterize BDNF methylation during recovery from TBI in children and investigate this novel biomarker as a potential biological mechanism underlying the known association between childhood adversity and poorer neurobehavioral outcomes following TBI in childhood. Findings from this research will contribute to an improved understanding of why some children display good recovery following TBI, whereas many others suffer from chronic neurobehavioral impairments.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Epigenetic Effects on Pediatric Traumatic Brain Injury Recovery (EETR): An Observational, Prospective, Longitudinal Concurrent Cohort Study Protocol.
Treble-Barna A, Patronick J, Uchani S, Marousis NC, et al · · 2020 · cited 10× · PMID 32595586 · DOI 10.3389/fneur.2020.00460
Verify or expand the search:
- PubMed search for NCT04186429
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other University of Pittsburgh trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04186429 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Pittsburgh
- Last refreshed: 19 September 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04186429.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing