NCT04178434 (e-SMINC) is a NA clinical trial of Internet-based CBT intervention in Myocardial Infarction, sponsored by Per Tornvall.

Who is sponsoring NCT04178434?

NCT04178434 is sponsored by Per Tornvall.

What drugs are being tested in NCT04178434?

Interventions in NCT04178434: Internet-based CBT intervention.

What condition does NCT04178434 study?

NCT04178434 studies Myocardial Infarction.

Is NCT04178434 still recruiting?

NCT04178434 is currently recruiting now. Last updated 7 March 2025.

Last reviewed 2025-03-07 · How we verify

NCT04178434: e-SMINC

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Internet-based Treatment of Stress and Anxiety in Myocardial Infarction With Non-obstructive Coronary Arteries

Recruiting now NA Last updated 7 March 2025

What this trial tests

NA trial testing Internet-based CBT intervention in Myocardial Infarction in 64 participants. Currently enrolling.

Timeline

11 November 2021

Primary endpoint
30 November 2024

30 November 2025

Quick facts

Lead sponsor	Per Tornvall
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	64
Start date	11 November 2021
Primary completion	30 November 2024
Estimated completion	30 November 2025
Sites	1 location across Sweden

Drugs / interventions tested

Internet-based CBT intervention

Conditions studied

Myocardial Infarction — all drugs for Myocardial Infarction →

Sponsor

Per Tornvall

Who can join

Adults 35 to 79, any sex, with Myocardial Infarction. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Patient with myocardial infarction with non-obstructive coronary arteries and takotsubo syndrome often have high levels of stress and anxiety. At present there are no treatment alternatives in this group of patients. Previously, cognitive behavioral therapy (CBT), primarily aiming at relieving stress, has been shown to decrease morbidity in patient with myocardial infarction with obstructive coronary arteries. The present open randomized study aims to decrease stress and anxiety in patients with myocardial infarction with non-obstructive coronary arteries and takotsubo syndrome by an internet-based CBT focusing on stress and anxiety.

Publications & conference data

5 peer-reviewed publications reference this trial (live from Europe PMC):

Reducing stress and anxiety in patients with myocardial infarction with non-obstructive coronary arteries or Takotsubo syndrome: A non-randomized feasibility study.
Rondung E, Humphries SM, Olsson EMG, Sundelin R, et al · · 2022 · cited 5× · PMID 35910688 · DOI 10.1016/j.invent.2022.100562
Designing a Web-Based Psychological Intervention for Patients With Myocardial Infarction With Nonobstructive Coronary Arteries: User-Centered Design Approach.
Humphries SM, Rondung E, Norlund F, Sundin Ö, et al · · 2020 · cited 5× · PMID 32940615 · DOI 10.2196/19066
The e-mental health treatment in Stockholm myocardial infarction with non-obstructive coronaries or Takotsubo syndrome study (E-SMINC): a study protocol for a randomised controlled trial.
Olsson EMG, Norlund F, Rondung E, Humphries SM, et al · · 2022 · cited 4× · PMID 35883115 · DOI 10.1186/s13063-022-06530-3
Myocardial infarction with nonobstructive coronary arteries (MINOCA): a narrative review.
Yang P, Zhang S, Yin X, Zhang Y, et al · · 2025 · cited 2× · PMID 40452049 · DOI 10.1186/s40001-025-02703-3
The e-mental health treatment in Stockholm myocardial infarction with non-obstructive coronaries or Takotsubo syndrome study (E-SMINC), a study protocol for a randomized controlled trial
Olsson EMG, Norlund F, Rondung E, Humphries SM, et al · · 2022 · DOI 10.21203/rs.3.rs-1581234/v1

Verify or expand the search:

Other trials of Internet-based CBT intervention

Trials testing the same drug.

NCT03322644 — Internet-based Pain Self-management for Persons With Acute Recurrent and Chronic Pancreatitis Pain · NA · completed

Other recruiting trials for Myocardial Infarction

Currently open trials in the same condition.

NCT07257198 — Aspirin-free Strategy With Ticagrelor in Patients With a Myocardial Infarction Treated Medically Alone · Phase 3 · recruiting
NCT07402642 — Effect of Early Educational Intervention on Cardiovascular Risk Factors After Acute Coronary Syndrome · NA · recruiting
NCT07301034 — A Research Study to Look at the Effect of Ziltivekimab on Plaque in the Blood Vessels of the Heart, Compared to Placebo, · Phase 3 · recruiting
NCT07142265 — Evaluation of 1-Year Clinical Outcomes With Early Inclisiran Initiation in Post-MI Patients · recruiting
NCT07138911 — Effect of Home-based Exercise Plan Mediated by Use of Digital Health App on Kinesiophobia and Functional Capacity · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04178434 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Per Tornvall
Last refreshed: 7 March 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04178434.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing