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NCT04177511: Stim-Endom
Treatment of Chronic Pelvic Pain Due to Endometriosis by Transcutaneous Auricular Vagus Nerve Stimulation
NA trial testing Transcutaneous Auricular Vagus Nerve Stimulation in Endometriosis in 72 participants. Currently enrolling.
28 March 2027
Quick facts
| Lead sponsor | Hopital Foch |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 72 |
| Start date | 13 December 2021 |
| Primary completion | 28 March 2027 |
| Estimated completion | 28 March 2027 |
| Sites | 1 location across France |
Drugs / interventions tested
- Transcutaneous Auricular Vagus Nerve Stimulation
Conditions studied
- Endometriosis — all drugs for Endometriosis →
Sponsor
Hopital Foch — full company profile →
Who can join
15 and older, female only, with Endometriosis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
6-10% of women of childbearing age suffer from endometriosis, which is mainly manifested by dysmenorrhea, non-menstrual pelvic pain and dyspareunia. Several treatment strategies, including surgical ones, are proposed but they are sometimes insufficient because endometriosis-related pain is frequently accompanied by sensitization. Endometriosis surgery, when indicated, is therefore changeably effective, even though the lesions have been completely resected. Patients therefore consult Pain Units seeking for the effective treatment as the pain persist even after surgical management of endometriosis. Vagus nerve stimulation is a non-invasive technique that includes an anti-inflammatory effect and a modulation of neurotransmitter production (adrenaline, norepinephrine; serotonin, acetylcholine). Yuan and Silberstein published a general review on the technique. Migraine and depression are one of the selected indications. In addition, Napadow et al. published favourable results in a short series of patients with chronic pelvic pain. The Investigators of this study have treated some patients with this technique with a result deemed satisfactory which leads to propose a randomized study to confirm this impression.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT04177511
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
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Related trials
Other trials of Transcutaneous Auricular Vagus Nerve Stimulation
Trials testing the same drug.
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- NCT06793800 — Effect of Transcutaneous Auricular Vagus Nerve Stimulation Application on Respiratory Functions in Stroke Patients · NA · recruiting
- NCT07000175 — Comparison of Heart Rate Variability Measurement on the Arm and Chest in Vagus Nerve Stimulation · NA · recruiting
- NCT06597149 — Effect of Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) on Plasma Insulin Levels · NA · recruiting
Other recruiting trials for Endometriosis
Currently open trials in the same condition.
- NCT06559852 — The Impact of Yoga on Endometriosis-Related Pain · NA · recruiting
- NCT07393295 — Efficacy and Tolerability of TENS in Endometriosis-related Pain · NA · recruiting
- NCT07134023 — Educational Program for the Multidisciplinary Support of Patients With Endometriosis · NA · recruiting
- NCT07240883 — ENDO1000 - A UK-wide Endometriosis Research Project · recruiting
- NCT06974773 — Remote Electrical Stimulation as a Long-term Intervention for Endometriosis Flare Ups · NA · recruiting
Other Hopital Foch trials
Trials by the same sponsor.
- NCT06980844 — Interpretation of the Role of Eosinophils in Diffuse Interstitial Pneumopathies · NA · not yet recruiting
- NCT06757244 — DOVIPA, a Study Evaluating Efficacy and Safety of DOstarlimab and VItamin D3 With mFOLFIRINOX in PAncreatic Cancer · Phase 2 · recruiting
- NCT06631794 — Evaluation of the Impact of a HPV Vaccination Talk with Third Grade Students · not yet recruiting
- NCT06533436 — Clinical and Economic Comparison of 2 Methods of Intubation Tube Fixation : AnchorFastTM Versus Current Cord Fixation · NA · recruiting
- NCT06476002 — Analysis of the Understanding of the French Version of the Vulvar Pain Assessment Questionnaire · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04177511 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Hopital Foch
- Last refreshed: 21 November 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04177511.
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