NCT04175990 is a Phase 1 clinical trial of Dydrogesterone Pill in IVF, sponsored by National University of Malaysia.

Who is sponsoring NCT04175990?

NCT04175990 is sponsored by National University of Malaysia.

What drugs are being tested in NCT04175990?

Interventions in NCT04175990: Dydrogesterone Pill.

What condition does NCT04175990 study?

NCT04175990 studies IVF, Oocyte Maturation Defect 1, Clinical Pregnancy Rate, Ovarian Hyperstimulation.

Is NCT04175990 still recruiting?

NCT04175990 is currently completed. Last updated 26 November 2019.

Last reviewed 2019-11-26 · How we verify

NCT04175990

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

IVF Outcome Following Progestogen Ovarian Stimulation

Completed Phase 1 Last updated 26 November 2019

What this trial tests

Phase 1 trial testing Dydrogesterone Pill in IVF in 155 participants. Completed in 9 May 2019.

Timeline

10 May 2018

Primary endpoint
10 March 2019

9 May 2019

Quick facts

Lead sponsor	National University of Malaysia
Phase	Phase 1
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	other
Enrollment	155
Start date	10 May 2018
Primary completion	10 March 2019
Estimated completion	9 May 2019
Sites	1 location across Malaysia

Drugs / interventions tested

Dydrogesterone Pill — full drug profile →

Conditions studied

IVF — all drugs for IVF →
Oocyte Maturation Defect 1 — all drugs for Oocyte Maturation Defect 1 →
Clinical Pregnancy Rate — all drugs for Clinical Pregnancy Rate →
Ovarian Hyperstimulation — all drugs for Ovarian Hyperstimulation →

Sponsor

National University of Malaysia

Who can join

Adults 20 to 40, female only, with IVF or Oocyte Maturation Defect 1. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The new strategy is by using the progestogen to block the luteinizing hormone(LH) surge either endogenous during luteal phase stimulation, or exogenous in the follicular phase i.e progestin primed ovarian stimulation (PPOS). The goal of PPOS is to develop a single dominant follicle. Various types of oral Progestin had been studied before including Medroxyprogesterone Acetate (MPA) and Utrogestan with different dosage. A different study by Wang et al conducted by using MPA to patients with PCOS. The use of MPA is contraindicated in human pregnancy whereas Dydrogesterone had been extensively used worldwide for the treatment of threatened miscarriage as well as luteal support in infertility setting. Previous protocol on PPOS showed inconclusive results. Therefore in this study, Dydrogesterone was used as the Progestin Primed Ovarian hyperstimulation to explore its effect on PCOS women IVF outcome.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Efficacy of progestin-primed ovarian stimulation in women with polycystic ovary syndrome undergoing <i>in vitro</i> fertilization: a systematic review and meta-analysis.
Yang L, Liang F, Yuan Y, Luo X, et al · · 2023 · cited 9× · PMID 37795363 · DOI 10.3389/fendo.2023.1224858

Verify or expand the search:

Other trials of Dydrogesterone Pill

Trials testing the same drug.

NCT07242131 — Efficacy of Oral Contraceptive, Progesterone, and Inositol on Menstrual Regulation in PCOS · NA · recruiting

Other recruiting trials for IVF

Currently open trials in the same condition.

NCT07364526 — Non-Invasive Preimplantation Genetic Screening for Aneuploidies and Clinical Outcomes in Egg Donation Patients · recruiting
NCT07088640 — Single Step Protocol and Multi-step Warming Protocol for Blastocyst FET · NA · recruiting
NCT06544837 — Trial to Evaluate the Clinical Utility of Non-invasive Endometrial Receptivity Test (Ora) in Patients With Implantation · NA · recruiting
NCT06334003 — Cardiometabolic Function in Offspring, Mother and Placenta After Assisted Reproductive Technology · recruiting
NCT06577181 — Effect of HCG on Endometrial Preparation in Frozen Embryo Transfer · active not recruiting

Other National University of Malaysia trials

Trials by the same sponsor.

NCT07251842 — Metabolic Availability of Methionine in Tempeh Chips Among Reproductive-age Women Using Indicator Amino Acid Oxidation ( · NA · not yet recruiting
NCT07362394 — Autologous Dentine Graft Compared to Xenograft in Managing Periodontally Compromised Second Molar After Third Molar Remo · NA · not yet recruiting
NCT07503223 — Sleep Optimization With Acoustic Therapy · NA · recruiting
NCT07432373 — Intrapleural Alteplase-Tyloxapol vs Intrapleural Alteplase-DNase in Pleural Infection · not yet recruiting
NCT07157397 — Effect of a Plant-Focused Diet on Nutritional Status in Malnourished Peritoneal Dialysis Patients · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04175990 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by National University of Malaysia
Last refreshed: 26 November 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04175990.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing