NCT04175691 (AISRNA) is a clinical trial of Sequencing of circRNA/miRNA/lncRNA in Acute Stroke, sponsored by Nanjing First Hospital, Nanjing Medical University.

Who is sponsoring NCT04175691?

NCT04175691 is sponsored by Nanjing First Hospital, Nanjing Medical University.

What drugs are being tested in NCT04175691?

Interventions in NCT04175691: Sequencing of circRNA/miRNA/lncRNA.

What condition does NCT04175691 study?

NCT04175691 studies Acute Stroke, Ischemic Stroke.

Is NCT04175691 still recruiting?

NCT04175691 is currently recruiting now. Last updated 15 April 2026.

Last reviewed 2026-04-15 · How we verify

NCT04175691: AISRNA

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Circulating Non-coding RNA in Acute Ischemic Stroke (AISRNA)

Recruiting now Last updated 15 April 2026

What this trial tests

trial testing Sequencing of circRNA/miRNA/lncRNA in Acute Stroke in 500 participants. Currently enrolling.

Timeline

24 November 2019

Primary endpoint
31 December 2026

31 December 2026

Quick facts

Lead sponsor	Nanjing First Hospital, Nanjing Medical University
Status	Recruiting now
Study type	OBSERVATIONAL
Enrollment	500
Start date	24 November 2019
Primary completion	31 December 2026
Estimated completion	31 December 2026
Sites	1 location across China

Drugs / interventions tested

Sequencing of circRNA/miRNA/lncRNA

Conditions studied

Acute Stroke — all drugs for Acute Stroke →
Ischemic Stroke — all drugs for Ischemic Stroke →

Sponsor

Nanjing First Hospital, Nanjing Medical University

Who can join

18 and older, any sex, with Acute Stroke or Ischemic Stroke. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

AISRNA is to analyze the expression pattern of circular RNA (circRNA), micro-RNA (miRNA) and long non-coding RNA (lncRNA) by next-generation sequencing in patients with acute ischemic stroke and healthy control. The candidate circRNA/miRNA/lncRNA will be verified as biomarkers for the detection and prognosis of acute ischemic stroke.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

Noncoding RNA therapeutics - challenges and potential solutions.
Winkle M, El-Daly SM, Fabbri M, Calin GA. · · 2021 · cited 1123× · PMID 34145432 · DOI 10.1038/s41573-021-00219-z
Roles of lncRNAs in brain development and pathogenesis: Emerging therapeutic opportunities.
Srinivas T, Mathias C, Oliveira-Mateos C, Guil S. · · 2023 · cited 76× · PMID 36793211 · DOI 10.1016/j.ymthe.2023.02.008
Therapeutic application of exosomes in ischaemic stroke.
Li Y, Tang Y, Yang GY. · · 2021 · cited 59× · PMID 33431513 · DOI 10.1136/svn-2020-000419
The emerging role and significance of circular RNAs in viral infections and antiviral immune responses: possible implication as theranostic agents.
Awan FM, Yang BB, Naz A, Hanif A, et al · · 2021 · cited 53× · PMID 32615049 · DOI 10.1080/15476286.2020.1790198
SNHG15 is a negative regulator of inflammation by mediating TRAF2 ubiquitination in stroke-induced immunosuppression.
Sun H, Li S, Xu Z, Liu C, et al · · 2022 · cited 30× · PMID 34980176 · DOI 10.1186/s12974-021-02372-z
Inflammatory Factors as Potential Markers of Early Neurological Deterioration in Acute Ischemic Stroke Patients Receiving Endovascular Therapy - The AISRNA Study.
Deng QW, Huang S, Li S, Zhai Q, et al · · 2021 · cited 18× · PMID 34511974 · DOI 10.2147/jir.s317147
The Genetic Basis of Strokes in Pediatric Populations and Insight into New Therapeutic Options.
Jankovic M, Petrovic B, Novakovic I, Brankovic S, et al · · 2022 · cited 15× · PMID 35163523 · DOI 10.3390/ijms23031601
Effects of edaravone dexborneol on functional outcome and inflammatory response in patients with acute ischemic stroke.
Chen W, Zhang H, Li Z, Deng Q, et al · · 2024 · cited 14× · PMID 38902691 · DOI 10.1186/s12883-024-03712-1

Verify or expand the search:

Other recruiting trials for Acute Stroke

Currently open trials in the same condition.

NCT07491952 — Continuous Dual Aspiration Technique With Zoom System for Stroke · recruiting
NCT07295366 — Early Administration of PCSK9 Inhibitors After Thrombectomy for Atherosclerotic Acute Ischemic Stroke: A Randomized Cont · Phase 4 · recruiting
NCT07355881 — mSOAR and Early Mortality in Acute Stroke · recruiting
NCT07301372 — Evaluation Study of Early Administration of Evolocumab After Thrombolysis in Patients With Atherosclerotic Acute Ischemi · Phase 4 · recruiting
NCT07167550 — The Study of Efficacy and Safety of Dimephosphon® in Acute Ischemic Stroke · Phase 3 · recruiting

Other Nanjing First Hospital, Nanjing Medical University trials

Trials by the same sponsor.

NCT07349979 — PCI With Guideline-Directed Medical Therapy for HFpEF Patients With Ischemic Cardiomyopathy · NA · not yet recruiting
NCT07505056 — Jianpi Lishi Jiedu Granules for Prevention of Postoperative Recurrence in Colorectal Advanced Adenomas · Phase 3 · not yet recruiting
NCT07397234 — Thyroid Cartilage Plane VS Superior Laryngeal Nerve Space Block in Awake Tracheal Intubation · NA · not yet recruiting
NCT07455448 — Antibiotic Resistance of Helicobacter Pylori in Nanjing: A Cross-Sectional Study · completed
NCT07385885 — Ultrasound-guided Non-invasive Simulation in Anesthesia Residency Training · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04175691 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Nanjing First Hospital, Nanjing Medical University
Last refreshed: 15 April 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04175691.

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