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NCT04172753
Feasibility of Online MR-guided Radiotherapy on a 1.5T MR-Linac
Recruiting now
NA
Last updated 21 November 2019
What this trial tests
NA trial testing Radiotherapy on the MR-Linac in Rectal Cancer in 472 participants. Currently enrolling.
Timeline
9 May 2018
Primary endpoint
9 May 2022
9 May 2022
9 May 2027
Quick facts
| Lead sponsor | University Hospital Tuebingen |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 472 |
| Start date | 9 May 2018 |
| Primary completion | 9 May 2022 |
| Estimated completion | 9 May 2027 |
| Sites | 1 location across Germany |
Drugs / interventions tested
- Radiotherapy on the MR-Linac
- Imaging on the MR Linac
Conditions studied
- Rectal Cancer — all drugs for Rectal Cancer →
- Head and Neck Cancer — all drugs for Head and Neck Cancer →
- Liver Cancer — all drugs for Liver Cancer →
- Breast Cancer — all drugs for Breast Cancer →
Sponsor
University Hospital Tuebingen
Who can join
18 and older, any sex, with Rectal Cancer or Head and Neck Cancer. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study investigates the feasibility of imaging and treatment on a novel 1.5 T MR-Linac radiotherapy hybrid device.
Publications & conference data
8 peer-reviewed publications reference this trial (live from Europe PMC):
-
MR-Guided Radiotherapy for Head and Neck Cancer: Current Developments, Perspectives, and Challenges.
Boeke S, Mönnich D, van Timmeren JE, Balermpas P. · · 2021 · cited 43× · PMID 33816247 · DOI 10.3389/fonc.2021.616156 -
Quantitative magnetic resonance imaging on hybrid magnetic resonance linear accelerators: Perspective on technical and clinical validation.
Thorwarth D, Ege M, Nachbar M, Mönnich D, et al · · 2020 · cited 35× · PMID 33458346 · DOI 10.1016/j.phro.2020.09.007 -
Magnetic Resonance-Guided Stereotactic Body Radiotherapy of Liver Tumors: Initial Clinical Experience and Patient-Reported Outcomes.
Weykamp F, Hoegen P, Klüter S, Spindeldreier CK, et al · · 2021 · cited 31× · PMID 34178616 · DOI 10.3389/fonc.2021.610637 -
Marker-less online MR-guided stereotactic body radiotherapy of liver metastases at a 1.5 T MR-Linac - Feasibility, workflow data and patient acceptance.
Gani C, Boeke S, McNair H, Ehlers J, et al · · 2021 · cited 28× · PMID 33319073 · DOI 10.1016/j.ctro.2020.11.014 -
1.5 T MR-linac planning study to compare two different strategies of rectal boost irradiation.
Bonomo P, Lo Russo M, Nachbar M, Boeke S, et al · · 2021 · cited 15× · PMID 33336086 · DOI 10.1016/j.ctro.2020.11.016 -
Analysis of the electron-stream effect in patients treated with partial breast irradiation using the 1.5 T MR-linear accelerator.
De-Colle C, Nachbar M, Mӧnnich D, Boeke S, et al · · 2021 · cited 14× · PMID 33553697 · DOI 10.1016/j.ctro.2020.12.005 -
Automatic 3D Monte-Carlo-based secondary dose calculation for online verification of 1.5 T magnetic resonance imaging guided radiotherapy.
Nachbar M, Mönnich D, Dohm O, Friedlein M, et al · · 2021 · cited 13× · PMID 34307914 · DOI 10.1016/j.phro.2021.05.002 -
Prospects for online adaptive radiation therapy (ART) for head and neck cancer.
Guberina M, Guberina N, Hoffmann C, Gogishvili A, et al · · 2024 · cited 12× · PMID 38191400 · DOI 10.1186/s13014-023-02390-6
Verify or expand the search:
- PubMed search for NCT04172753
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
Data sources for this page
- Trial protocol + status: ClinicalTrials.gov NCT04172753 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Hospital Tuebingen
- Last refreshed: 21 November 2019
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04172753.
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