NCT04171882

Microglial Cells Activation Imaging Using PET-CT With 18F-DPA714

Status unknown Last updated 23 November 2021

What this trial tests

trial in Microglial Cells Activation Imaging in 500 participants. Status unknown.

Timeline

1 November 2019

Primary endpoint
1 November 2024

1 November 2024

Quick facts

Lead sponsor	Weibing Miao, PhD
Status	Status unknown
Study type	OBSERVATIONAL
Enrollment	500
Start date	1 November 2019
Primary completion	1 November 2024
Estimated completion	1 November 2024
Sites	2 locations across China

Conditions studied

• Microglial Cells Activation Imaging — all drugs for Microglial Cells Activation Imaging →

Sponsor

Weibing Miao, PhD

Who can join

Adults 18 to 80, any sex, with Microglial Cells Activation Imaging. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

There is accumulating evidence suggesting that inflammatory processes, through microglial activation, would play a key role in brain injury and degeneration. It is considered that microglial activation would be part of self-propelling cycle of neuroinflammation that fuels Neurologic deterioration. It is however hard to evidence microglial activation in vivo: first, the investigators need very high-resolution imaging tools and then, the only ligand available to date, 11C-PK11195, has a low sensitivity and specificity and provided heterogeneous results. 18F-DPA-714 is a new PET ligand which labels microglial cells. The investigators aim to explore the clinical feasibility used PET-CT with 18F-DPA714 to monitor microglial cells activation of brain in several different disease. This study might reveal significant neuroinflammatory process in the brain. The results of this study might provide a new biomarker of disease pathological progression and help as identifying subjects who might most benefit from a specific anti-inflammatory drug.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

1. Novel PET Imaging of Inflammatory Targets and Cells for the Diagnosis and Monitoring of Giant Cell Arteritis and Polymyalgia Rheumatica.
   van der Geest KSM, Sandovici M, Nienhuis PH, Slart RHJA, et al · · 2022 · cited 21× · PMID 35733858 · DOI 10.3389/fmed.2022.902155
2. Novel Tracers and Radionuclides in PET Imaging.
   Mason C, Gimblet GR, Lapi SE, Lewis JS. · · 2021 · cited 10× · PMID 34392925 · DOI 10.1016/j.rcl.2021.05.012
3. DPA714 PET Imaging Shows That Inflammation of the Choroid Plexus Is Active in Chronic-Phase Intracerebral Hemorrhage.
   Yao S, Gao Z, Fang W, Fu Y, et al · · 2024 · cited 4× · PMID 38054504 · DOI 10.1097/rlu.0000000000004948
4. Inflammation of central nervous system fiber tracts is active in patients over six months post-intracerebral hemorrhage.
   Gao Z, Lian K, Lin F, Chen W, et al · · 2025 · cited 1× · PMID 41126352 · DOI 10.1186/s40478-025-02139-0