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NCT04170517: ProFET
Serum Progesterone Levels on the Day of Frozen Embryo Transfer (FET) and Pregnancy Outcomes
trial testing Measurement of serum progesterone on the day of FET in Infertility in 402 participants. Completed in 31 December 2021.
28 February 2021
Quick facts
| Lead sponsor | CARE Fertility UK |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 402 |
| Start date | 2 January 2020 |
| Primary completion | 28 February 2021 |
| Estimated completion | 31 December 2021 |
| Sites | 1 location across United Kingdom |
Drugs / interventions tested
- Measurement of serum progesterone on the day of FET
Conditions studied
- Infertility — all drugs for Infertility →
- Infertility, Female — all drugs for Infertility, Female →
- IVF — all drugs for IVF →
Sponsor
CARE Fertility UK
Who can join
Eligibility, female only, with Infertility or Infertility, Female. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Frozen embryo transfer (FET) cycles have become more common in recent years due to a push towards elective single embryo transfer (SET). While it is known that progesterone supplementation during the luteal phase improves clinical pregnancy rates, there is a paucity of prospective data on the impact of serum progesterone levels on pregnancy outcomes in FET cycles. This multicentre prospective cohort study aims to investigate the association between serum progesterone levels on the day of FET and pregnancy outcomes, and to determine a serum progesterone cut-off value above which clinical pregnancy and live birth are more likely to occur. Women undergoing ART-FET cycles at CARE Fertility clinics in the UK will be recruited and their serum progesterone measured on the day of frozen embryo transfer. Follow-up data will be stored in electronic patient records and analysed to determine whether a low serum progesterone level on the day of FET adversely affects ART outcomes.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
The effect of frozen embryo transfer regimen on the association between serum progesterone and live birth: a multicentre prospective cohort study (ProFET).
Melo P, Wood S, Petsas G, Chung Y, et al · · 2022 · cited 15× · PMID 36518987 · DOI 10.1093/hropen/hoac054
Verify or expand the search:
- PubMed search for NCT04170517
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other CARE Fertility UK trials
Trials by the same sponsor.
- NCT06765512 — Artificial Intelligence-Based Machine Learning to Diagnose and Classify Adenomyosis from Ultrasound Scans: a Multicentre · active not recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04170517 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by CARE Fertility UK
- Last refreshed: 29 August 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04170517.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing