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NCT04167722: EXOPRO

How Does Prostate Cancer Metastasize? Studying the Role of Secreted Packages (Exosomes) From Fat Tissue in Lean and Obese Patients

Status unknown Last updated 22 September 2021
What this trial tests

trial testing Robotic Radical Prostatectomy in Prostate Cancer in 100 participants. Status unknown.

Timeline
1 October 2019
Primary endpoint
1 October 2023
1 October 2024

Quick facts

Lead sponsorImperial College London
StatusStatus unknown
Study typeOBSERVATIONAL
Enrollment100
Start date1 October 2019
Primary completion1 October 2023
Estimated completion1 October 2024
Sites1 location across United Kingdom

Drugs / interventions tested

Conditions studied

Sponsor

Imperial College London

Who can join

Eligibility, male only, with Prostate Cancer or Obesity. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The investigators will be collecting prostate and fat tissue from participants undergoing radical prostatectomy to culture and study in the laboratory.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

  1. Clinical applications of stem cell-derived exosomes.
    Tan F, Li X, Wang Z, Li J, et al · · 2024 · cited 390× · PMID 38212307 · DOI 10.1038/s41392-023-01704-0
  2. Cancer-Derived Exosomes: Their Role in Cancer Biology and Biomarker Development.
    Kok VC, Yu CC. · · 2020 · cited 318× · PMID 33116515 · DOI 10.2147/ijn.s272378
  3. Potential Use of Exosomes as Diagnostic Biomarkers and in Targeted Drug Delivery: Progress in Clinical and Preclinical Applications.
    Huda MN, Nafiujjaman M, Deaguero IG, Okonkwo J, et al · · 2021 · cited 160× · PMID 33988964 · DOI 10.1021/acsbiomaterials.1c00217
  4. Cancer nanotechnology: current status and perspectives.
    Kemp JA, Kwon YJ. · · 2021 · cited 117× · PMID 34727233 · DOI 10.1186/s40580-021-00282-7
  5. Clinical applications for exosomes: Are we there yet?
    Perocheau D, Touramanidou L, Gurung S, Gissen P, et al · · 2021 · cited 101× · PMID 33751579 · DOI 10.1111/bph.15432
  6. The impact of obesity on adipocyte-derived extracellular vesicles.
    Kwan HY, Chen M, Xu K, Chen B. · · 2021 · cited 59× · PMID 34677643 · DOI 10.1007/s00018-021-03973-w
  7. Pathogenetic Features and Current Management of Glioblastoma.
    Nguyen HM, Guz-Montgomery K, Lowe DB, Saha D. · · 2021 · cited 42× · PMID 33670551 · DOI 10.3390/cancers13040856
  8. Adult Stem Cell-Derived Extracellular Vesicles in Cancer Treatment: Opportunities and Challenges.
    Parfejevs V, Sagini K, Buss A, Sobolevska K, et al · · 2020 · cited 32× · PMID 32397238 · DOI 10.3390/cells9051171

Verify or expand the search:

Other recruiting trials for Prostate Cancer

Currently open trials in the same condition.

Other Imperial College London trials

Trials by the same sponsor.

Verify against primary sources

Data sources for this page

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