Who is sponsoring NCT04163354?

NCT04163354 is sponsored by The University of Hong Kong.

What drugs are being tested in NCT04163354?

Interventions in NCT04163354: 5% sodium fluoride varnish (NaF), Glass ionomer sealant (GIS).

What condition does NCT04163354 study?

NCT04163354 studies Pit and Fissure Caries, Glass Ionomer Cements, Tooth, Deciduous, Child.

Is NCT04163354 still recruiting?

NCT04163354 is currently status unknown. Last updated 14 November 2019.

Last reviewed 2019-11-14 · How we verify

NCT04163354

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Glass Ionomer Sealant Versus Fluoride Varnish on Occlusal Caries Prevention

Status unknown NA Last updated 14 November 2019

What this trial tests

NA trial testing 5% sodium fluoride varnish (NaF) in Pit and Fissure Caries in 348 participants. Status unknown.

Timeline

11 April 2018

Primary endpoint
31 August 2021

31 December 2022

Quick facts

Lead sponsor	The University of Hong Kong
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	prevention
Enrollment	348
Start date	11 April 2018
Primary completion	31 August 2021
Estimated completion	31 December 2022
Sites	1 location across Hong Kong

Drugs / interventions tested

5% sodium fluoride varnish (NaF)
Glass ionomer sealant (GIS)

Conditions studied

Pit and Fissure Caries — all drugs for Pit and Fissure Caries →
Glass Ionomer Cements — all drugs for Glass Ionomer Cements →
Tooth, Deciduous — all drugs for Tooth, Deciduous →
Child — all drugs for Child →

Sponsor

The University of Hong Kong

Who can join

Adults 3 to 5, any sex, with Pit and Fissure Caries or Glass Ionomer Cements. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The current study compares the efficacy of glass ionomer fissure sealant versus topical application of 5% sodium fluoride varnish in prevention of occlusal caries among preschool children.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

Pit and fissure sealants versus fluoride varnishes for preventing dental decay in the permanent teeth of children and adolescents.
Kashbour W, Gupta P, Worthington HV, Boyers D. · · 2020 · cited 56× · PMID 33142363 · DOI 10.1002/14651858.cd003067.pub5
Nonrestorative Caries Treatment: A Systematic Review Update.
Cabalén MB, Molina GF, Bono A, Burrow MF. · · 2022 · cited 28× · PMID 35879115 · DOI 10.1016/j.identj.2022.06.022
Glass Ionomer Sealant versus Fluoride Varnish Application to Prevent Occlusal Caries in Primary Second Molars among Preschool Children: A Randomized Controlled Trial.
Ying Lam PP, Sardana D, Luo W, Ekambaram M, et al · · 2021 · cited 8× · PMID 34284374 · DOI 10.1159/000517390
Glass ionomer fissure sealants versus fluoride varnish application on children's behaviour: a randomised controlled trial.
Chiu HHC, Lam PPY, Yiu CKY. · · 2025 · cited 2× · PMID 39495397 · DOI 10.1007/s40368-024-00952-0

Verify or expand the search:

Other The University of Hong Kong trials

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04163354 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by The University of Hong Kong
Last refreshed: 14 November 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04163354.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing