NCT04158479

China Extracorporeal Life Support Registry

Recruiting now Last updated 9 April 2024

What this trial tests

trial testing ECMO in Cardiogenic Shock in 20,000 participants. Currently enrolling.

Timeline

1 January 2017

Primary endpoint
31 December 2030

31 December 2030

Quick facts

Lead sponsor	Beijing Anzhen Hospital
Status	Recruiting now
Study type	OBSERVATIONAL
Enrollment	20,000
Start date	1 January 2017
Primary completion	31 December 2030
Estimated completion	31 December 2030
Sites	1 location across China

Drugs / interventions tested

• ECMO

Conditions studied

• Cardiogenic Shock — all drugs for Cardiogenic Shock →
• Cardiac Arrest — all drugs for Cardiac Arrest →
• Heart Failure — all drugs for Heart Failure →
• Acute Respiratory Distress Syndrome — all drugs for Acute Respiratory Distress Syndrome →

Sponsor

Beijing Anzhen Hospital

Who can join

Eligibility, any sex, with Cardiogenic Shock or Cardiac Arrest. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Extracorporeal life support (ECLS), also known as extracorporeal membrane oxygenation (ECMO), is an extracorporeal technique of providing effective cardiac and respiratory support to patients with lungs and/or heart failure. There was a growth in ECLS cases, centers, and center scale in China during the past decade.

This multi-center registry was conducted by Chinese Society of Extracorporeal Life Support. The objectives were to investigate China statistics of ECLS and to evaluate the short-term and long-term outcomes of patients with ECLS.

Publications & conference data

7 peer-reviewed publications reference this trial (live from Europe PMC):

1. Impact of renal complications on outcome in adult patients with acute fulminant myocarditis receiving venoarterial extracorporeal membrane oxygenation: an analysis of nationwide CSECLS database in China.
   Hao T, Chen L, Wu C, Xie J, et al · · 2023 · cited 8× · PMID 37755544 · DOI 10.1186/s13613-023-01186-x
2. Clinical characteristics of extracorporeal cardiopulmonary resuscitation in China: a multicenter retrospective study.
   Yuan Z, Liu Y, Wei G, Wang F, et al · · 2024 · cited 2× · PMID 38987696 · DOI 10.1186/s12871-024-02618-2
3. Impact of early PaCO<sub>2</sub> and pH fluctuations on neurological outcomes in ARDS patients receiving VV ECMO: a retrospective cohort study from the CSECLS registry.
   Chen X, Xie J, Wang Y, Du Z, et al · · 2025 · cited 1× · PMID 40999113 · DOI 10.1186/s13613-025-01570-9
4. Exploration of the Clinical Assessment and Prognostic Value of Society for Cardiovascular Angiography and Intervention Shock Staging in Patients With Acute Myocardial Infarction and Cardiogenic Shock on Veno-arterial Extracorporeal Membrane Oxygenation Support
   Dong K, Zhao J, Pan C, Cai W, et al · · 2026
5. Association between preoperative vasoactive inotropic score and clinical outcomes in severe pneumonia patients with sepsis undergoing extracorporeal membrane oxygenation: an analysis from the Chinese Society of ExtraCorporeal Life Support (CSECLS) Registry.
   Chen W, Wang B, Zhou Y, Li C, et al · · 2026 · PMID 41620775 · DOI 10.1186/s40001-026-03932-w
6. Current situation, efficacy, and safety of extracorporeal cardiopulmonary resuscitation in China.
   Liu Y, Han X, QiQi, Yuan Z, et al · · 2022 · PMID 36745768 · DOI 10.1097/cm9.0000000000002455
7. Clinical Outcome and Risk Factors for Acute Fulminant Myocarditis Supported by Venoarterial Extracorporeal Membrane Oxygenation: an Analysis of Nationwide CSECLS Database in China Mainland
   Hao T, Jiang Y, Wu C, Li C, et al · · 2021 · DOI 10.21203/rs.3.rs-739094/v1