NCT04155333 is a NA clinical trial of Transcranial direct current stimulation in Performance Enhancement, sponsored by United States Army Aeromedical Research Laboratory.

Who is sponsoring NCT04155333?

NCT04155333 is sponsored by United States Army Aeromedical Research Laboratory.

What drugs are being tested in NCT04155333?

Interventions in NCT04155333: Transcranial direct current stimulation.

What condition does NCT04155333 study?

NCT04155333 studies Performance Enhancement.

Is NCT04155333 still recruiting?

NCT04155333 is currently completed. Last updated 25 January 2022.

Last reviewed 2022-01-25 · How we verify

NCT04155333

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effects of Non-Invasive Brain Stimulation on Soldiers' Cognitive and Functional Performance

Completed NA Last updated 25 January 2022

What this trial tests

NA trial testing Transcranial direct current stimulation in Performance Enhancement in 28 participants. Completed in 30 September 2021.

Timeline

12 December 2019

Primary endpoint
1 June 2021

30 September 2021

Quick facts

Lead sponsor	United States Army Aeromedical Research Laboratory
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	single
Primary purpose	basic science
Enrollment	28
Start date	12 December 2019
Primary completion	1 June 2021
Estimated completion	30 September 2021
Sites	1 location across United States

Drugs / interventions tested

Transcranial direct current stimulation

Conditions studied

Performance Enhancement — all drugs for Performance Enhancement →

Sponsor

United States Army Aeromedical Research Laboratory

Who can join

Adults 18 to 40, any sex, with Performance Enhancement. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Non-invasive brain stimulation has been shown to alter performance in both clinical and healthy populations on cognitive tasks. While the performance alterations have generally been shown to result in enhancement, mixed results remain in the literature. Much of the mixed results within the literature have been attributed to the use of different stimulation parameters, targeting of different brain areas, and using a variety of performance measures or assessing different constructs. However, non-invasive brain stimulation is a desirable method for enhancing Soldier performance given the ease of administration and minimal side effects as compared to other forms of performance enhancement (e.g., pharmaceuticals, caffeine). The objective of the current study is to evaluate the effects of non-invasive brain stimulation to the left dorsolateral prefrontal cortex in enhancing Soldier cognitive skills and performance on military tasks. A double blind within-subjects design will be used with healthy, rested Soldiers who will receive non-invasive brain stimulation and perform basic cognitive and operationally relevant tasks.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Limitations associated with transcranial direct current stimulation for enhancement: considerations of performance tradeoffs in active-duty Soldiers.
Duffy MJ, Feltman KA, Kelley AM, Mackie R. · · 2024 · cited 4× · PMID 39132676 · DOI 10.3389/fnhum.2024.1444450

Verify or expand the search:

Other trials of Transcranial direct current stimulation

Trials testing the same drug.

NCT07444242 — Accelerated Treatment of Depressive Patients With tDCS · NA · not yet recruiting
NCT07433972 — Changes in Hemodynamic Response Following Transcranial Electrical Stimulation in Sroke Individuals · NA · not yet recruiting
NCT07257601 — TDCS-RTMS Intervention for Motor Function · NA · not yet recruiting
NCT06501820 — Neural Control of Gait & Navigation in ADRD · NA · enrolling by invitation
NCT06976697 — Home-Based tDCS Treatment Of Major Depressive Disorder · NA · recruiting

Other recruiting trials for Performance Enhancement

Currently open trials in the same condition.

NCT07510893 — Augmented Feedback Effects on Shoulder Rotator Performance · NA · recruiting
NCT07289594 — Impact of Psychosocial Support Web-Based Toolkit · NA · active not recruiting

Other United States Army Aeromedical Research Laboratory trials

Trials by the same sponsor.

NCT05611814 — Preliminary Evaluation of an Osteopathic Manipulative Treatment (OMT) to Prevent Motion Sickness Symptoms · NA · completed
NCT04697901 — Sustaining Aviator Performance During Extended Operational Flight · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04155333 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by United States Army Aeromedical Research Laboratory
Last refreshed: 25 January 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04155333.

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