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NCT04153812
Clinical Study on the Safety and Effectiveness of Vagus Nerve Stimulation in the Treatment of Refractory Depression
Phase 1, PHASE2 trial testing vagus nerve stimulation in Refractory Depression in 10 participants. Status unknown.
1 October 2021
Quick facts
| Lead sponsor | Xijing Hospital |
|---|---|
| Phase | Phase 1, PHASE2 |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 10 |
| Start date | 1 November 2019 |
| Primary completion | 1 October 2021 |
| Estimated completion | 30 May 2022 |
| Sites | 1 location across China |
Drugs / interventions tested
- vagus nerve stimulation
Conditions studied
- Refractory Depression — all drugs for Refractory Depression →
Sponsor
Xijing Hospital
Who can join
Adults 18 to 65, any sex, with Refractory Depression. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Based on the mechanism hypothesis and clinical efficacy of VNS in treating refractory depression, this study will evaluate the safety and efficacy of VNS in treating refractory depression through a small sample of clinical trials
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Treatment resistance in psychiatry: state of the art and new directions.
Howes OD, Thase ME, Pillinger T. · · 2022 · cited 250× · PMID 34257409 · DOI 10.1038/s41380-021-01200-3
Verify or expand the search:
- PubMed search for NCT04153812
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of vagus nerve stimulation
Trials testing the same drug.
- NCT07528742 — Vagus Nerve Stimulation for Reaction Time · NA · recruiting
- NCT06473623 — Non-invasive Auricular Fiber Vagus Nerve Stimulation (afVNS) for Treatment of Autism Spectrum Disorder · NA · recruiting
- NCT05586412 — Efficacy of Auricular Vagus Nerve Stimulation · NA · unknown
- NCT07097025 — 2-Year Study of Vagus Nerve Stimulation for Higher-Grade Treatment-Resistant Depression: Clinical Outcomes and Policy Re · completed
Other Xijing Hospital trials
Trials by the same sponsor.
- NCT07532096 — Extended Sentinel Lymph Node Biopsy With Methylene Blue Single Tracer Post-Neoadjuvant Therapy for Node-Positive Breast · NA · not yet recruiting
- NCT07519018 — TIS for Drug Resistant TLE · NA · not yet recruiting
- NCT07518992 — Correlation Between Preoperative Sleep and Postoperative Brain and Renal Dysfunction · not yet recruiting
- NCT07466303 — Serplulimab Combined With Trastuzumab Rezetecan as Neoadjuvant Therapy for Triple-Negative Breast Cancer · Phase 2 · not yet recruiting
- NCT07474142 — A Multicenter, Prospective Study on the Prognostic Value of PSMA PET in Patients With Newly Diagnosed, Treatment-naïve P · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04153812 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Xijing Hospital
- Last refreshed: 6 November 2019
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04153812.
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