Adults 18 to 70, any sex, with PTSD. Patients with the condition only — healthy volunteers not accepted.
Results — posted to ClinicalTrials.gov
Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.
Skin Conductance ResponsesPrimary· Study visit day 4: during administration of fear extinction memory.
Main protocol: Threat reactivity as quantified by skin conductance responses to a conditioned and subsequently extinguished stimulus versus a never conditioned stimulus.
Group
Value
95% CI
Active tDCS During Extinction Learning Followed by Sham tDCS During Consolidation
0.075
± 0.025
Sham tDCS During Extinction Followed by Active tDCS During Consolidation
0.088
± 0.026
Sham tDCS During Extinction Followed by Sham tDCS During Consolidation
0.057
± 0.025
Adverse events — posted to ClinicalTrials.gov
Time frame: One day, following active tDCS or sham stimulation.
Reporting threshold: 0%.
Adverse-event reports describe events observed during the trial — not all are caused by the drug.
Group 1: Active tDCS During Extinction Learning and Sham tDCS During Consolidation
Serious: 0/19 (0%)
Deaths: 0/19
Group 2: Sham tDCS During Extinction Learning and Active tDCS During Consolidation
Serious: 0/20 (0%)
Deaths: 0/20
Group 3: Sham tDCS During Extinction Learning and Sham tDCS During Consolidation
The primary purpose of this study is to investigate the effects of tDCS timing on extinction memory in PTSD. A total of 90 participants will be randomized equally across one of three groups:
1. One group receiving active stimulation during extinction followed by sham stimulation during consolidation
2. One group receiving sham stimulation during extinction followed by active stimulation during consolidation
3. One group receiving sham stimulation both during extinction and consolidation
This study also includes an online sub-study (Aim 2) focused on contextual processing along the PTSD spectrum. The online study tests if there is an association between threat and non-threat learning in contextual and non-contextual situations. A maximum of 500 participants will be recruited using an online, panel-based platform.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
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Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Butler Hospital
Last refreshed: 21 October 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04152772.