Last reviewed · How we verify
NCT04151927
Effects of Overnight Low Oxygen Exposure on Energy Balance
NA trial testing Normobaric Hypoxia in Resting Metabolic Rate in 20 participants. Completed in 2 October 2021.
2 October 2021
Quick facts
| Lead sponsor | Florida State University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | single |
| Primary purpose | basic science |
| Enrollment | 20 |
| Start date | 11 December 2019 |
| Primary completion | 2 October 2021 |
| Estimated completion | 2 October 2021 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Normobaric Hypoxia
- Normobaric Normoxia
Conditions studied
- Resting Metabolic Rate — all drugs for Resting Metabolic Rate →
- Appetite — all drugs for Appetite →
- Heart Rate Variability — all drugs for Heart Rate Variability →
Sponsor
Florida State University
Who can join
Adults 20 to 45, any sex, with Resting Metabolic Rate or Appetite. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This research study will evaluate changes in resting metabolic rate, appetite, and heart rate variability following overnight exposure (8 h/night) to normobaric hypoxia (NH) or normobaric normoxic (NN). In randomized order, participants will sleep one night in NH conditions (\~15% oxygen; achieved with nitrogen dilution, equivalent to \~8500 feet elevation) and another night in NN (control) conditions (\~20% oxygen; achieved with nitrogen dilution, equivalent to \~1000 feet elevation).
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
An Overnight, 8-Hour Low Oxygen Exposure Increases Energy Expenditure with No Effect on Energy Intake: A Randomized, Sham-Controlled, Crossover Study.
Baker PA, Long AN, Dawson MA, Berryman CE. · · 2026 · PMID 41500361 · DOI 10.1016/j.tjnut.2025.101319
Verify or expand the search:
- PubMed search for NCT04151927
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04151927 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Florida State University
- Last refreshed: 29 November 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04151927.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing