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NCT04150653: AAA multiphase
Non-invasive Aortic Aneurysm Tissue Characterization Using Wall Viscoelasticity
trial testing Multiphase scan CT, non-invasive vascular ultrasound elastography by ultrasound (NIVE) in Abdominal Aortic Aneurysm Without Rupture in 30 participants. Status unknown.
31 December 2023
Quick facts
| Lead sponsor | Centre hospitalier de l'Université de Montréal (CHUM) |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 30 |
| Start date | 1 September 2020 |
| Primary completion | 31 December 2023 |
| Estimated completion | 31 December 2024 |
| Sites | 1 location across Canada |
Drugs / interventions tested
- Multiphase scan CT, non-invasive vascular ultrasound elastography by ultrasound (NIVE)
Conditions studied
- Abdominal Aortic Aneurysm Without Rupture — all drugs for Abdominal Aortic Aneurysm Without Rupture →
Sponsor
Centre hospitalier de l'Université de Montréal (CHUM)
Who can join
18 and older, any sex, with Abdominal Aortic Aneurysm Without Rupture. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Abdominal aortic aneurysm (AAA) is an abnormal dilatation of the aorta in the abdomen due to a wall weakening caused by atherosclerosis. While indications for a rupture intervention are based on AAA maximal diameter (MaxD) (5 cm), 23% of ruptured AAAs are less than 5 cm and in large AAAs, rupture rate could be lower than expected. We propose to expand and validate our vascular ultrasound elastography software to 3D. Strain maps generated from radiofrequency (RF) data acquired from 30 AAA patients with a matrix-array 3D probe will be registered to conventional CT (phase 1) and validated to a biomechanical for characterization of AAA wall, assessing vulnerability and influence of surrounding tissues (phase 2). At the end of the project, we will have analyzed 3D strain maps to improve patient selection before surgery.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT04150653
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
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Related trials
Other recruiting trials for Abdominal Aortic Aneurysm Without Rupture
Currently open trials in the same condition.
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- NCT04894864 — Opioid Free Anesthesia-Analgesia Strategy and Surgical Stress in Elective Open Abdominal Aortic Aneurysm Repair · Phase 4 · recruiting
- NCT03298477 — EVAS2 IDE Prospective, Multicenter, Single Arm Safety and Effectiveness Confirmatory Study · NA · active not recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04150653 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Centre hospitalier de l'Université de Montréal (CHUM)
- Last refreshed: 10 March 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04150653.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing