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NCT04148690: GANC-TZ

Assessing the Impact of Group Antenatal Care on IPTp Uptake in Tanzania

Terminated NA Last updated 29 July 2021
What this trial tests

NA trial testing Group antenatal care (GANC) in Malaria in 4,515 participants. Terminated before completion.

Timeline
15 November 2019
Primary endpoint
10 July 2021
10 July 2021

Quick facts

Lead sponsorCenters for Disease Control and Prevention
PhaseNA
StatusTerminated
Study typeINTERVENTIONAL
Allocationrandomized
Designparallel
Maskingsingle
Primary purposehealth services research
Enrollment4,515
Start date15 November 2019
Primary completion10 July 2021
Estimated completion10 July 2021
Sites1 location across Tanzania

Drugs / interventions tested

Conditions studied

Sponsor

Centers for Disease Control and Prevention — full company profile →

Who can join

Adults 15 to 45, female only, with Malaria or Malaria in Pregnancy. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Group antenatal care (GANC) is a service delivery model where women with pregnancies of similar gestational age are brought together for antenatal care (ANC), incorporating information sharing and peer support. This model provides selected aspects of clinical care to women in the group at the same time during group visits, as well as creating a support group of women at a similar stage in pregnancy, to improve the quality of care and engagement of women in the ANC process, ultimately leading to better retention in care. Initial studies have suggested that this improves uptake of intermittent preventive treatment in pregnancy (IPTp) among women who participate, but have not evaluated the effect at community level. The investigators propose to assess whether use of the GANC model in Tanzania can improve the quality of ANC as compared to standard individual ANC, by measuring uptake of recommended interventions, primarily IPTp. Recent data from Tanzania and Kenya suggest that malaria parasitemia prevalence among pregnant women correlates with the prevalence among children under five, and could be used to track trends over time.3-5 The very high coverage of ANC (\>80% attending at least one ANC contact), suggests that pregnant women could be a good sentinel population that could be readily tracked over time. However, pregnant women represent only about 5% of the overall population, thus, it is important to demonstrate that the trends in malaria prevalence and household level coverage of interventions reported by pregnant women attending ANC is representative of coverage among the general population. If validated, these data could be used to augment or even replace the data on coverage of interventions collected through the use of malaria indicator surveys, which are expensive and infrequently conducted, and generally only powered to the regional level.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

  1. Using antenatal care as a platform for malaria surveillance data collection: study protocol.
    Gutman JR, Mwesigwa JN, Arnett K, Kangale C, et al · · 2023 · cited 8× · PMID 36932384 · DOI 10.1186/s12936-023-04521-6

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