NCT04144803 (BOPRA) is a clinical trial of Cerebral near-infrared spectroscopy in Critically Ill, sponsored by Helsinki University Central Hospital.

Who is sponsoring NCT04144803?

NCT04144803 is sponsored by Helsinki University Central Hospital.

What drugs are being tested in NCT04144803?

Interventions in NCT04144803: Cerebral near-infrared spectroscopy.

What condition does NCT04144803 study?

NCT04144803 studies Critically Ill, Major Trauma, Anesthesia, Emergencies.

Is NCT04144803 still recruiting?

NCT04144803 is currently status unknown. Last updated 28 October 2022.

Last reviewed 2022-10-28 · How we verify

NCT04144803: BOPRA

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Brain Oxygenation During Prehospital Anesthesia: an Observational Study

Status unknown Last updated 28 October 2022

What this trial tests

trial testing Cerebral near-infrared spectroscopy in Critically Ill in 1,300 participants. Status unknown.

Timeline

18 November 2019

Primary endpoint
25 September 2022

31 December 2023

Quick facts

Lead sponsor	Helsinki University Central Hospital
Status	Status unknown
Study type	OBSERVATIONAL
Enrollment	1,300
Start date	18 November 2019
Primary completion	25 September 2022
Estimated completion	31 December 2023
Sites	6 locations across Finland

Drugs / interventions tested

Cerebral near-infrared spectroscopy

Conditions studied

Critically Ill — all drugs for Critically Ill →
Major Trauma — all drugs for Major Trauma →
Anesthesia — all drugs for Anesthesia →
Emergencies — all drugs for Emergencies →

Sponsor

Helsinki University Central Hospital

Who can join

18 and older, any sex, with Critically Ill or Major Trauma. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Brain oxygenation of adult patients undergoing prehospital emergency anesthesia is monitored using noninvasive near-infrared spectroscopy. Patients are afterwards interviewed to define neurological outcome to measure quality of life. The purpose of this study is to reveal the risk factors of prehospital anesthesia related cerebral desaturation events (CDE) and to define the association between CDE and survival, neurological outcome or quality of life.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Cerebral oxygen desaturation events during and functional outcomes after prehospital anaesthesia: A prospective pilot study.
Nurmi J, Laukkanen-Nevala P, Kirves H, Raatiniemi L, et al · · 2022 · cited 4× · PMID 35338647 · DOI 10.1111/aas.14066
Association of Cerebral Oxygenation During Prehospital Anaesthesia and Functional Outcome: A Prospective, Observational Multi-Centre Cohort Study of 1014 Patients.
Saviluoto A, Raatiniemi L, Mäkelä S, Toivonen T, et al · · 2026 · cited 2× · PMID 41359999 · DOI 10.1111/aas.70161

Verify or expand the search:

Other trials of Cerebral near-infrared spectroscopy

Trials testing the same drug.

NCT05708105 — Prediction of Intraventricular Hemorrhage Using Echocardiography and Near Infrared Spectroscopy · recruiting

Other recruiting trials for Critically Ill

Currently open trials in the same condition.

NCT07222007 — Induction Agent Choice With Early Mortality and Prognostic Outcomes in Critically Ill Patients · recruiting
NCT07143695 — Parasternal Intercostal Muscle Thickening as an Additive Weaning Criterion · NA · recruiting
NCT06473844 — Efficacy of SGLT2 Inhibitors in Adults With Sepsis · NA · recruiting
NCT05055830 — Opportunistic PK/PD Trial in Critically Ill Children (OPTIC) · recruiting
NCT05112328 — The Effects of Pancreatic Enzyme Supplementation in Critically Ill Patients on Enteral Feeding · NA · recruiting

Other Helsinki University Central Hospital trials

Trials by the same sponsor.

NCT07423637 — The Impact of Early Automated Insulin Delivery (AID) Therapy on Diabetes Control and Comorbidities, and Cost-effectivene · NA · not yet recruiting
NCT07462559 — KF2025#1 Trial: Ketamine, Cannabidiol and Cobicistat Interaction Study · Phase 1 · not yet recruiting
NCT07458984 — FMT Capsules for rCDI · Phase 3 · not yet recruiting
NCT07001423 — ChOlecystectomy aFter successFul Endoscopic Common Bile Duct Stone Extraction in Elderly · NA · recruiting
NCT07155629 — Neoadjuvant Treatment vs Upfront Surgery for Left-Sided Pancreatic Cancer · Phase 3 · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04144803 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Helsinki University Central Hospital
Last refreshed: 28 October 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04144803.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing