NCT04141956: OHE-REA

Incidence of Use of High-Flow Nasal Cannula Oxygen Therapy in Intensive Care Units Patients

Completed Last updated 17 March 2025

What this trial tests

trial testing High-Flow Nasal Cannula in Oxygen Deficiency in 257 participants. Completed in 30 October 2020.

Timeline

2 November 2019

Primary endpoint
30 October 2020

30 October 2020

Quick facts

Lead sponsor	Nantes University Hospital
Status	Completed
Study type	OBSERVATIONAL
Enrollment	257
Start date	2 November 2019
Primary completion	30 October 2020
Estimated completion	30 October 2020
Sites	10 locations across France

Drugs / interventions tested

• High-Flow Nasal Cannula

Conditions studied

• Oxygen Deficiency — all drugs for Oxygen Deficiency →

Sponsor

Nantes University Hospital

Who can join

Adults 18 to 99, any sex, with Oxygen Deficiency. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Patients with one or more organ failure (heart, lung) require hospitalization in intensive care where these failures can be managed. Nearly 30% of patients in intensive care units are hospitalized for acute respiratory distress (lung failure). This failure occurs in about 20% of postoperative patient, but it can also occur in the context of a pathology specific to the lung or after weaning of mechanical ventilation.

It is therefore interesting to develop several techniques to provide oxygen to these patients with the aim in particular to avoid the use of intubation (insertion of a tube into the trachea to achieve artificial ventilation). For the past ten years, High-Flow Nasal Canula (HFNC) has developed. This technique reduces the need for intubation but the studies are contradictory, however they agree on its ease of use and the few risks associated with it. The principle of this technique is to deliver a humidified and heated gas mixture at a high rate through large nasal cannula. The advantage of this device is its non-invasive and the possibility of administering a large amount of oxygen. There is a certain craze for this oxygenation technique despite few scientific studies in the literature. However, it requires the expertise of the medical and paramedical team so as not to delay intubation.

The investigators propose to carry out an observational study (without any modification of the usual practices) with epidemiological aim in order to make an inventory of the modes of use of the HFNC, in particular on its frequency of use and on its duration of use per patient hospitalized in intensive care. The investigators will recruit all HFNC patients in intensive care units (20 centers) (30 patients / center): 15 after weaning of mechanical ventilation and 15 others for other reasons. Patients will be followed every day and up to 48 hours after removal of the HFNC.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. High-flow nasal-cannula oxygen therapy in intensive-care-unit patients: a prospective multicenter observational cohort study (OHE-REA).
   Compagne P, Ehrmann S, Jonas M, Morin J, et al · · 2026 · PMID 41735369 · DOI 10.1038/s41598-026-39969-4