Last reviewed · How we verify
NCT04140422: EDEMAS
Eye Drops for Early Morning-Associated Corneal Swelling of the Cornea
NA trial testing Hyperosmolar eye drops in Fuchs' Endothelial Dystrophy in 68 participants. Completed in 25 June 2020.
25 June 2020
Quick facts
| Lead sponsor | University Eye Hospital, Freiburg |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 68 |
| Start date | 24 October 2019 |
| Primary completion | 25 June 2020 |
| Estimated completion | 25 June 2020 |
| Sites | 1 location across Germany |
Drugs / interventions tested
- Hyperosmolar eye drops
- Placebo
Conditions studied
- Fuchs' Endothelial Dystrophy — all drugs for Fuchs' Endothelial Dystrophy →
Sponsor
University Eye Hospital, Freiburg
Who can join
Adults 18 to 100, any sex, with Fuchs' Endothelial Dystrophy. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study evaluates the efficacy of hyperosmolar eye drops on early morning edema of the cornea in patients with Fuchs' endothelial corneal dystrophy (FECD). Each participant will receive hyperosmolar eye drops in one eye and lubricating eye drops in the fellow eye.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Graft Detachment after Descemet Membrane Endothelial Keratoplasty with and without Cataract Surgery.
Kladny AS, Zander DB, Lieberum JL, Glatz A, et al · · 2022 · cited 10× · PMID 36531572 · DOI 10.1016/j.xops.2022.100194 -
Therapeutic future of Fuchs endothelial corneal dystrophy: An ongoing way to explore.
Liu JX, Chiang TL, Hung KF, Sun YC. · · 2024 · cited 5× · PMID 38654984 · DOI 10.4103/tjo.tjo-d-23-00115
Verify or expand the search:
- PubMed search for NCT04140422
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Fuchs' Endothelial Dystrophy
Currently open trials in the same condition.
- NCT06261346 — Plasma Rich in Growth Factors in Corneal Endothelial Transplantation · NA · recruiting
- NCT06881771 — FECD-TRACE: Fuchs' Endothelial Corneal Dystrophy TRAjectory and Correlation With Genotype in the United Kingdom · recruiting
- NCT05275972 — Descemet Endothelial Thickness Comparison Trial II · Phase 3 · recruiting
- NCT05636579 — Study to Assess Safety and Tolerability of Multiple Doses of EO2002 · Phase 1 · recruiting
- NCT05436665 — The Belgian Endothelial Surgical Transplant of the Cornea · NA · recruiting
Other University Eye Hospital, Freiburg trials
Trials by the same sponsor.
- NCT05399095 — Supine Positioning for Graft Attachment After Descemet Membrane Endothelial Keratoplasty · NA · completed
- NCT01962571 — Treatment of Optic Neuritis With Erythropoietin: a Randomised, Double-blind, Placebo-controlled Trial · Phase 3 · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04140422 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Eye Hospital, Freiburg
- Last refreshed: 15 July 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04140422.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing