NCT04134689

DOT Selfie: A Mobile Technology Intervention to Evaluate Treatment Adherence Among Tuberculosis Patients

Completed NA Last updated 25 July 2023

What this trial tests

NA trial testing DOT Selfie Intervention in Tuberculosis in 144 participants. Completed in 30 April 2023.

Timeline

13 July 2020

Primary endpoint
31 March 2022

30 April 2023

Quick facts

Lead sponsor	University of Georgia
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	health services research
Enrollment	144
Start date	13 July 2020
Primary completion	31 March 2022
Estimated completion	30 April 2023
Sites	1 location across Uganda

Drugs / interventions tested

• DOT Selfie Intervention
• In-person DOT

Conditions studied

• Tuberculosis — all drugs for Tuberculosis →

Sponsor

University of Georgia

Who can join

Adults 18 to 65, any sex, with Tuberculosis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This is a randomized controlled trial (RCT) to determine whether Video Observed Treatment (VDOT) using social internet bundle incentives for tuberculosis (TB) is an effective way to improve medication adherence in TB treatment, compared with standard in-person treatment (home-/ community-based).

The study will include two study arms: one will receive TB treatment using the standard in-person DOT, and the other through VDOT. All patients (regardless of study arm) will receive daily TB treatment under home- or community-based observation . For patients in the In-person DOT arm, this will be observed and recorded daily by a study nurse. Patients in the VDOT arm however, will be required to record and upload their daily medication intake using a mobile phone App. As a form of incentive, these patients will be rewarded with social internet bundles for every 7 consecutive video uploads. Additionally, they will be sent motivational text messages to encourage treatment compliance.

Regardless of study arm, all patients will have 2,4, and 6 monthly clinic visits for clinical and/or sputum assessments. Each patient will also complete a Morisky Medication Adherence Scale (MMAS) questionnaire at treatment completion.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. Using a Mobile Health Intervention (DOT Selfie) With Transfer of Social Bundle Incentives to Increase Treatment Adherence in Tuberculosis Patients in Uganda: Protocol for a Randomized Controlled Trial.
   Sekandi JN, Onuoha NA, Buregyeya E, Zalwango S, et al · · 2021 · cited 11× · PMID 32990629 · DOI 10.2196/18029
2. Effectiveness of a Mobile Health Intervention (DOT Selfie) in Increasing Treatment Adherence Monitoring and Support for Patients With Tuberculosis in Uganda: Randomized Controlled Trial.
   Sekandi JN, Buregyeya E, Zalwango S, Nakkonde D, et al · · 2025 · cited 4× · PMID 39715573 · DOI 10.2196/57991