Last reviewed · How we verify
NCT04132791: TImE ASPIRIN
TIME ASPIRIN: Chronotherapy With Aspirin for Reduction of Cardiovascular Disease
NA trial testing placebo after awakening + aspirin before bedtime in Cardiovascular Diseases in 328 participants. Terminated before completion.
31 March 2022
Quick facts
| Lead sponsor | Leiden University Medical Center |
|---|---|
| Phase | NA |
| Status | Terminated |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 328 |
| Start date | 7 October 2019 |
| Primary completion | 31 March 2022 |
| Estimated completion | 31 March 2022 |
| Sites | 1 location across Netherlands |
Drugs / interventions tested
- placebo after awakening + aspirin before bedtime
- aspirin after awakening + placebo before bedtime
Conditions studied
- Cardiovascular Diseases — all drugs for Cardiovascular Diseases →
Sponsor
Leiden University Medical Center
Who can join
18 and older, any sex, with Cardiovascular Diseases. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study will be a comparative effectiveness research to determine the difference in major adverse cardiovascular events between the group with aspirin after awakening and placebo before bedtime and the group with placebo after awakening and aspirin before bedtime.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Therapeutic Development by Targeting the cGAS-STING Pathway in Autoimmune Disease and Cancer.
Li Q, Tian S, Liang J, Fan J, et al · · 2021 · cited 27× · PMID 34867409 · DOI 10.3389/fphar.2021.779425 -
Beyond DNA sensing: expanding the role of cGAS/STING in immunity and diseases.
Seok JK, Kim M, Kang HC, Cho YY, et al · · 2023 · cited 18× · PMID 37354378 · DOI 10.1007/s12272-023-01452-3
Verify or expand the search:
- PubMed search for NCT04132791
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Leiden University Medical Center trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04132791 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Leiden University Medical Center
- Last refreshed: 24 June 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04132791.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing