Last reviewed · How we verify
NCT04131764
Diagnosis of ON With or Without MS or NMOSD
trial testing Reflex (Brightlamp Inc., Purdue University) in Multiple Sclerosis in 112 participants. Terminated before completion.
6 September 2022
Quick facts
| Lead sponsor | Jagannadha R Avasarala |
|---|---|
| Status | Terminated |
| Study type | OBSERVATIONAL |
| Enrollment | 112 |
| Start date | 4 October 2019 |
| Primary completion | 6 September 2022 |
| Estimated completion | 6 September 2022 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Reflex (Brightlamp Inc., Purdue University)
Conditions studied
- Multiple Sclerosis — all drugs for Multiple Sclerosis →
- Neuromyelitis Optica Spectrum Disorder Attack — all drugs for Neuromyelitis Optica Spectrum Disorder Attack →
- Neuromyelitis Optica Spectrum Disorder Relapse — all drugs for Neuromyelitis Optica Spectrum Disorder Relapse →
- Neuromyelitis Optica Spectrum Disorder Progression — all drugs for Neuromyelitis Optica Spectrum Disorder Progression →
Sponsor
Jagannadha R Avasarala
Who can join
Adults 18 to 90, any sex, with Multiple Sclerosis or Neuromyelitis Optica Spectrum Disorder Attack. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This is both a prospective and retrospective study of patients with a known diagnosis of optic neuritis (ON) only, multiple sclerosis (MS) with ON, or neuromyelitis spectrum disorder (NMOSD) with ON. There will be no requirement for blinding (patient or assessor) and data collected with the Reflex app will be compared against other data that track optic nerve functional status, such as optical coherence tomography (OCT), visual fields (VF), low-contrast sensitivity, MRI orbits/brain and visual evoked potentials (VEP). Patients who have any diagnosis of ON, with or without a diagnosis of MS or NMOSD and who have had testing using other modalities such as VEPs, VF, low-contrast sensitivity studies, OCT, and MRI of brain or orbits will be included as retrospective subjects in the study. In this cohort, RAPD assessments will be completed and compared to against the data that has accrued as noted.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT04131764
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Jagannadha R Avasarala trials
Trials by the same sponsor.
- NCT04131673 — MS and NMOSD in African-Americans · withdrawn
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04131764 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Jagannadha R Avasarala
- Last refreshed: 14 November 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04131764.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing