Last reviewed · How we verify
NCT04130867
Rehabilitation Manometry Study
trial testing pHRM in Oropharyngeal Dysphagia in 4 participants. Completed in 21 April 2021.
21 April 2021
Quick facts
| Lead sponsor | University of Wisconsin, Madison |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 4 |
| Start date | 11 November 2020 |
| Primary completion | 21 April 2021 |
| Estimated completion | 21 April 2021 |
| Sites | 1 location across United States |
Drugs / interventions tested
- pHRM
- VFSS
Conditions studied
- Oropharyngeal Dysphagia — all drugs for Oropharyngeal Dysphagia →
Sponsor
University of Wisconsin, Madison
Who can join
Adults 18 to 99, any sex, with Oropharyngeal Dysphagia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Oropharyngeal dysphagia, or difficulty swallowing, is a devastating condition that affects physiological and psychosocial functioning in 1 in 25 adults. Many dysphagia treatments exist, but our ability to adequately measure treatment outcomes is limited. Pharyngeal high-resolution manometry (pHRM) directly measures swallowing pressures, providing an objective measurement of physiology that characterizes the basic mechanisms of swallowing. pHRM is well-poised to measure outcomes of dysphagia treatments due to its direct, objective, and reproducible measures of swallowing function. This proposed project will address a central hypotheses that objective swallowing measures (including (pHRM) will reveal treatment-mediated swallowing changes, will align with patient-reported outcome measures, and will be able to predict who will benefit from treatment. The investigators will follow a cohort of participants with oropharyngeal dysphagia as they undergo either pharyngeal strengthening therapy or relief of upper esophageal sphincter outlet obstruction at three time points: baseline, mid-treatment (4-6 weeks) and post-treatment (10-12 weeks). The investigators will compare participants to healthy controls using pHRM, videofluoroscopy, diet assessment, functional reserve tests, and patient-reported outcome measures.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT04130867
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Related trials
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Currently open trials in the same condition.
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Other University of Wisconsin, Madison trials
Trials by the same sponsor.
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- NCT07470723 — The ORIGIN-FH Study · NA · recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04130867 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Wisconsin, Madison
- Last refreshed: 29 October 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04130867.
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