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NCT04129112: TCI
Evaluation of Influencing Variables in Awakening Concentration and Concentration at Body Movements of Propofol TCI (Targeted Controlled Infusion) Targeted at the Effector Site
trial testing We do not modify the normale general anesthesia delivery. We note the concentration of propofol at the effector site of body movementsand awakening in Awareness, Anesthesia in 75 participants. Completed in 15 December 2019.
15 December 2019
Quick facts
| Lead sponsor | University of Padova |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 75 |
| Start date | 1 July 2019 |
| Primary completion | 15 December 2019 |
| Estimated completion | 15 December 2019 |
| Sites | 1 location across Italy |
Drugs / interventions tested
- We do not modify the normale general anesthesia delivery. We note the concentration of propofol at the effector site of body movementsand awakening
Conditions studied
- Awareness, Anesthesia — all drugs for Awareness, Anesthesia →
Sponsor
University of Padova
Who can join
Adults 18 to 90, any sex, with Awareness, Anesthesia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Age has been related to awakening propofol concentration at effector site of TCI, but not to the loss of consciousness concentration, neither to the concentration of body movements during surgery, that can be interpreted as a sign of light anesthesia and lead to awareness. This study aims to determinate the incidence and the propofol TCI concentration at the effector site, in patients undergoing general anaesthesia without NBDs, of any patients body movements, defined as any spontaneous movements (but no reflex movements) during surgery.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
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Age influences on Propofol estimated brain concentration and entropy during maintenance and at return of consciousness during total intravenous anesthesia with target-controlled infusion in unparalyzed patients: An observational prospective trial.
Linassi F, Kreuzer M, Maran E, Farnia A, et al · · 2020 · cited 8× · PMID 33351856 · DOI 10.1371/journal.pone.0244145
Verify or expand the search:
- PubMed search for NCT04129112
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04129112 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Padova
- Last refreshed: 9 October 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04129112.
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