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NCT04128124: ENTROPY-ICU
Entropy Analysis and Complex Patient-ventilator Interactions During Mechanical Ventilation
trial testing processing signals of airway pressure and airway flow to calculate entropy in Patient Ventilator Interactions in 107 participants. Completed in 1 December 2019.
1 December 2019
Quick facts
| Lead sponsor | Corporacion Parc Tauli |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 107 |
| Start date | 1 September 2019 |
| Primary completion | 1 December 2019 |
| Estimated completion | 1 December 2019 |
| Sites | 1 location across Spain |
Drugs / interventions tested
- processing signals of airway pressure and airway flow to calculate entropy
Conditions studied
- Patient Ventilator Interactions — all drugs for Patient Ventilator Interactions →
- Spontaneous Breathing Trial — all drugs for Spontaneous Breathing Trial →
Sponsor
Corporacion Parc Tauli — full company profile →
Who can join
18 and older, any sex, with Patient Ventilator Interactions or Spontaneous Breathing Trial. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Complex patterns of patient-ventilator interactions could be miscalculated by visual observation of mechanical ventilator screens or current algorithms based on physiologic waveforms to detect patient-ventilator asynchronies. Therefore, we aim to characterize, validate and study the clinical distribution and implications of an automated and personalized non-invasive tool based on Entropy to detect Complex Patient-Ventilator Interactions (CP-VI) during mechanical ventilation, defined as breathing pattern change and/or clusters of asynchronies, over the signals of airway pressure (Paw) and airway flow (Flow).
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Development and validation of a sample entropy-based method to identify complex patient-ventilator interactions during mechanical ventilation.
Sarlabous L, Aquino-Esperanza J, Magrans R, de Haro C, et al · · 2020 · cited 7× · PMID 32807815 · DOI 10.1038/s41598-020-70814-4
Verify or expand the search:
- PubMed search for NCT04128124
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04128124 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Corporacion Parc Tauli
- Last refreshed: 7 July 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04128124.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing