NCT04127890 (EDEN) is a NA clinical trial of ELO Water in Diabetes Mellitus, sponsored by Changi General Hospital.

Who is sponsoring NCT04127890?

NCT04127890 is sponsored by Changi General Hospital.

What drugs are being tested in NCT04127890?

Interventions in NCT04127890: ELO Water, Placebo drinking water.

What condition does NCT04127890 study?

NCT04127890 studies Diabetes Mellitus.

Is NCT04127890 still recruiting?

NCT04127890 is currently completed. Last updated 27 January 2020.

Last reviewed 2020-01-27 · How we verify

NCT04127890: EDEN

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

ELO Water In Diabetes Care For Enhancement Of Blood Sugar Control

Completed NA Last updated 27 January 2020

What this trial tests

NA trial testing ELO Water in Diabetes Mellitus in 150 participants. Completed in 28 May 2018.

Timeline

7 March 2017

Primary endpoint
28 May 2018

28 May 2018

Quick facts

Lead sponsor	Changi General Hospital
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	treatment
Enrollment	150
Start date	7 March 2017
Primary completion	28 May 2018
Estimated completion	28 May 2018
Sites	1 location across Singapore

Drugs / interventions tested

ELO Water
Placebo drinking water

Conditions studied

Diabetes Mellitus — all drugs for Diabetes Mellitus →

Sponsor

Changi General Hospital

Who can join

Adults 21 to 70, any sex, with Diabetes Mellitus. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This double-blinded, randomised and controlled trial evaluates the efficacy of oxygen-enriched ELO drinking water as an adjuvant modality in diabetes care for enhancement of glycemic control in patients with Type 2 diabetes mellitus. Adults with type 2 diabetes will be randomized to drink 1.5 L of either ELO water or normal drinking water for 24 weeks. The primary outcome is improvement in glycaemic control.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Effects of water stably-enriched with oxygen as a novel method of tissue oxygenation on mitochondrial function, and as adjuvant therapy for type 2 diabetes in a randomized placebo-controlled trial.
Khoo J, Hagemeyer CE, Henstridge DC, Kumble S, et al · · 2021 · cited 1× · PMID 34260650 · DOI 10.1371/journal.pone.0254619

Verify or expand the search:

Other recruiting trials for Diabetes Mellitus

Currently open trials in the same condition.

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NCT07425275 — Integrated Oral Care Intervention for Xerostomia in Diabetes Patients · NA · recruiting
NCT06918977 — Improving Glycemic Control With Telemedicine and Smart Insulin Pens · NA · recruiting

Other Changi General Hospital trials

Trials by the same sponsor.

NCT07297745 — Trial of Aldosterone-hybrid SteRoid for Guiding curablE Treatment of Primary Aldosteronism (TARGET-PA) · NA · not yet recruiting
NCT07205133 — A Randomized Controlled Trial Comparing Whole Body Vibration Therapy With Usual Care and Usual Care to Improve Muscle He · NA · recruiting
NCT06970717 — Programmable Smart Watch for Remote Pre-habilitation/Rehabilitation Monitoring · NA · not yet recruiting
NCT06890169 — OneSTOP (One-Stop Telehealth Obesity Program) for Multidisciplinary Weight Management and Related Comorbidities · NA · recruiting
NCT06304415 — Elevated Lipoprotein(a) in Hospital Staff · active not recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04127890 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Changi General Hospital
Last refreshed: 27 January 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04127890.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing