Who is sponsoring NCT04127734?

NCT04127734 is sponsored by Radboud University Medical Center.

What condition does NCT04127734 study?

NCT04127734 studies Anastomotic Leak Rectum, Rectal Cancer.

Is NCT04127734 still recruiting?

NCT04127734 is currently status unknown. Last updated 21 October 2019.

Last reviewed 2019-10-21 · How we verify

NCT04127734: TENTACLE:R

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Treatment of Anastomotic Leakage After Rectal Cancer Resection

Status unknown Last updated 21 October 2019

What this trial tests

trial testing The efficacy of various interventions for anastomotic leakage after rectal cancer resection are investigated in Anastomotic Leak Rectum in 1,246 participants. Status unknown.

Timeline

1 April 2020

Primary endpoint
31 December 2020

30 September 2021

Quick facts

Lead sponsor	Radboud University Medical Center
Status	Status unknown
Study type	OBSERVATIONAL
Enrollment	1,246
Start date	1 April 2020
Primary completion	31 December 2020
Estimated completion	30 September 2021

Drugs / interventions tested

The efficacy of various interventions for anastomotic leakage after rectal cancer resection are investigated

Conditions studied

Anastomotic Leak Rectum — all drugs for Anastomotic Leak Rectum →
Rectal Cancer — all drugs for Rectal Cancer →

Sponsor

Radboud University Medical Center

Who can join

18 and older, any sex, with Anastomotic Leak Rectum or Rectal Cancer. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The TENTACLE: Rectum study is a multinational retrospective cohort study that includes patients with anastomotic leakage after rectal cancer resection. The study aims to develop an anastomotic leakage severity score and to evaluate the efficacy of different treatments of anastomotic leakage.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Stoma-free Survival After Rectal Cancer Resection With Anastomotic Leakage: Development and Validation of a Prediction Model in a Large International Cohort.
Greijdanus NG, Wienholts K, Ubels S, Talboom K, et al · · 2023 · cited 20× · PMID 37498208 · DOI 10.1097/sla.0000000000006043
Stoma-free survival after anastomotic leak following rectal cancer resection: worldwide cohort of 2470 patients.
Greijdanus NG, Wienholts K, Ubels S, Talboom K, et al · · 2023 · cited 10× · PMID 37819790 · DOI 10.1093/bjs/znad311
Colorectal-vaginal fistula after rectal cancer resection: international comparative cohort study of characteristics and treatment.
van Lieshout ML, Lemmens JMG, Greijdanus NG, Wienholts K, et al · · 2025 · PMID 41251615 · DOI 10.1093/bjs/znaf189

Verify or expand the search:

Other recruiting trials for Anastomotic Leak Rectum

Currently open trials in the same condition.

NCT05174910 — Investigation of the Benefit of Using an Autologous Platelet-rich Fibrin Matrix (Obsidian ASG®) for Treatment of Anastom · NA · active not recruiting

Other Radboud University Medical Center trials

Trials by the same sponsor.

NCT07485569 — Drug Repurposing in Thyroid Carcinoma: a Feasibility Trial · Phase 1 · not yet recruiting
NCT07514325 — MR-guided Adaptive Stereotactic Radiotherapy for Endometrial Cancer · NA · not yet recruiting
NCT07530263 — Deposition of Inhaled Liposomal Amphotericin B in Chronic Pulmonary Aspergillosis (CPA) · Phase 1 · not yet recruiting
NCT07532577 — Intranasal Insulin to Prevent Intensive Care Unit Delirium · Phase 2, PHASE3 · not yet recruiting
NCT07504172 — Real-world Effectiveness and Dosing Patterns of Tirzepatide in People With Obesity · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04127734 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Radboud University Medical Center
Last refreshed: 21 October 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04127734.

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