NCT04127240

The Effect of the DASH Diet Containing Meat on Muscle and Metabolic Health in Older Adults

Completed NA Last updated 15 October 2019

What this trial tests

NA trial testing DASH diet containing daily intakes of red meat in Obesity in 46 participants. Completed in 10 November 2018.

Timeline

15 June 2017

Primary endpoint
10 November 2018

10 November 2018

Quick facts

Lead sponsor	South Dakota State University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	other
Enrollment	46
Start date	15 June 2017
Primary completion	10 November 2018
Estimated completion	10 November 2018
Sites	1 location across United States

Drugs / interventions tested

• DASH diet containing daily intakes of red meat

Conditions studied

• Obesity — all drugs for Obesity →
• Sarcopenia — all drugs for Sarcopenia →
• Aging — all drugs for Aging →

Sponsor

South Dakota State University

Who can join

65 and older, any sex, with Obesity or Sarcopenia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Age-related changes in body composition, muscular fitness, and metabolic health resulting in the onset of obesity, sarcopenia, and chronic diseases are profound public health issues that are in need of immediate attention. Effective and feasible methods, such as dietary therapies, are needed to improve health in older adults that in turn lead to independence, enhanced quality of life and reduced hospitalizations. Diet quality and dietary protein intake are vital for maintaining body composition, muscle mass and improved physical performance. Malnutrition in dietary protein intake is a major cause of reduced muscle mass, strength, and function in older adults. The Dietary Approaches to Stop Hypertension (DASH) dietary pattern is a high-quality therapeutic diet known to improve health status in various diverse and at-risk populations resulting in improved heart health, maintained cognitive function and reductions in metabolic diseases such as diabetes, metabolic syndrome, and nonalcoholic fatty liver disease. The primary protein recommendations of the DASH diet are poultry and fish and it is recommended to decrease or exclude red meats from the diet. However, studies have demonstrated that lean red meat incorporated into a DASH-like diet doesn't exacerbate cardiovascular health indices in adults, indicating that lean red meat can be included in the DASH diet without negative effects on heart health. Although studies have reported on the DASH diet in older adults, no studies have investigated the effect of the DASH diet containing lean red meat on measures of body composition, muscle mass or metabolic health under controlled-feeding conditions. The purpose of this study was to determine the effect of the DASH diet containing daily intakes of lean red meat on indicators of body composition, muscular fitness and biomarkers of metabolic health in adults 65 and older using controlled-feeding and systems biology approaches.

Publications & conference data

5 peer-reviewed publications reference this trial (live from Europe PMC):

1. A Calorie-Restricted DASH Diet Reduces Body Fat and Maintains Muscle Strength in Obese Older Adults.
   Perry CA, Van Guilder GP, Kauffman A, Hossain M. · · 2019 · cited 31× · PMID 31905920 · DOI 10.3390/nu12010102
2. Decreased myostatin in response to a controlled DASH diet is associated with improved body composition and cardiometabolic biomarkers in older adults: results from a controlled-feeding diet intervention study.
   Perry CA, Van Guilder GP, Butterick TA. · · 2022 · cited 12× · PMID 35287731 · DOI 10.1186/s40795-022-00516-9
3. Cardiometabolic Changes in Response to a Calorie-Restricted DASH Diet in Obese Older Adults.
   Perry CA, Van Guilder GP, Hossain M, Kauffman A. · · 2021 · cited 11× · PMID 33816541 · DOI 10.3389/fnut.2021.647847
4. Changes in Choline Metabolites and Ceramides in Response to a DASH-Style Diet in Older Adults.
   Tate BN, Van Guilder GP, Aly M, Spence LA, et al · · 2023 · cited 10× · PMID 37686719 · DOI 10.3390/nu15173687
5. Choline in immunity: a key regulator of immune cell activation and function.
   Maia C, Fung CW, Sanchez-Lopez E. · · 2025 · cited 2× · PMID 40821837 · DOI 10.3389/fimmu.2025.1617077