NCT04123197 (MIMS3) is a NA clinical trial of Stress Challenge in Myocardial Infarction, sponsored by Emory University.

Who is sponsoring NCT04123197?

NCT04123197 is sponsored by Emory University.

What drugs are being tested in NCT04123197?

Interventions in NCT04123197: Stress Challenge.

What condition does NCT04123197 study?

NCT04123197 studies Myocardial Infarction.

Is NCT04123197 still recruiting?

NCT04123197 is currently completed. Last updated 12 August 2025.

Last reviewed 2025-08-12 · How we verify

NCT04123197: MIMS3

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Mental Stress and Myocardial Ischemia After MI: Sex Differences, Mechanisms and Prognosis

Completed NA Last updated 12 August 2025

What this trial tests

NA trial testing Stress Challenge in Myocardial Infarction in 311 participants. Completed in 31 May 2025.

Timeline

28 February 2020

Primary endpoint
31 May 2025

31 May 2025

Quick facts

Lead sponsor	Emory University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	basic science
Enrollment	311
Start date	28 February 2020
Primary completion	31 May 2025
Estimated completion	31 May 2025
Sites	3 locations across United States

Drugs / interventions tested

Stress Challenge

Conditions studied

Myocardial Infarction — all drugs for Myocardial Infarction →

Sponsor

Emory University

Who can join

Adults 18 to 60, any sex, with Myocardial Infarction. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this study is to look at the link between emotional stress and heart disease in men and women. Taking part in this study involves one clinic visit, one week of at home monitoring, and follow up phone calls every 6 months for 3 years.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Early Life Trauma Is Associated With Increased Microvolt T-Wave Alternans During Mental Stress Challenge: A Substudy of Mental Stress Ischemia: Prognosis and Genetic Influences.
Shah AJ, Weeks V, Lampert R, Bremner JD, et al · · 2022 · cited 4× · PMID 35167312 · DOI 10.1161/jaha.121.021582

Verify or expand the search:

Other recruiting trials for Myocardial Infarction

Currently open trials in the same condition.

NCT07257198 — Aspirin-free Strategy With Ticagrelor in Patients With a Myocardial Infarction Treated Medically Alone · Phase 3 · recruiting
NCT07402642 — Effect of Early Educational Intervention on Cardiovascular Risk Factors After Acute Coronary Syndrome · NA · recruiting
NCT07301034 — A Research Study to Look at the Effect of Ziltivekimab on Plaque in the Blood Vessels of the Heart, Compared to Placebo, · Phase 3 · recruiting
NCT07142265 — Evaluation of 1-Year Clinical Outcomes With Early Inclisiran Initiation in Post-MI Patients · recruiting
NCT07138911 — Effect of Home-based Exercise Plan Mediated by Use of Digital Health App on Kinesiophobia and Functional Capacity · NA · recruiting

Other Emory University trials

Trials by the same sponsor.

NCT06143345 — HIIT in Isolated IFG: A Proof-of-Concept Study · NA · withdrawn
NCT07189819 — Innovative Closed-loop Functional Electrical Stimulation Control System for Augmenting Post-stroke Gait · NA · not yet recruiting
NCT06451055 — Low-calorie Diet in Isolated Impaired Fasting Glucose · NA · not yet recruiting
NCT07405476 — Zanidatamab Before Surgery for the Treatment of HER2 Positive Colon and Rectal Cancer in Patients Planned for Curative I · Phase 2 · recruiting
NCT06708351 — Enhancing Cervical Cancer Screening and Treatment in Women Living With HIV in Kenya, the ENHANCE LINKAge Trial · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04123197 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Emory University
Last refreshed: 12 August 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04123197.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing