A Prospective Randomized Controlled Trial on the Use of Cerebral Oximetry in Adult Chinese Patients Undergoing Liver Transplantation (LT)

NCT04122027 NA UNKNOWN

Liver transplantation (LT) is a life-saving procedure for patients with end-stage liver diseases. Although with continuous advancement in technology, it remains a high-risk operation. The goal of LT is not only ensure survival of the patients but also to restore them back to their pre-morbid state with a good quality of life. Neurological sequelae can have major impact on postoperative outcomes after LT and yet the reported literature is scarce. Studies from Western countries showed some evidence on the use of cerebral oximtery in cardiac surgery to prevent neurological mishaps. LT shares similar intra-operative fluctuation of the haemodynamices as in cardiac surgery, causing disturbances in regional cerebral oxygenation and theorectically cerebral oximetry should be of great value as well in LT surgery. Data from a large randomised controlled trial is lacking from the current literatures. We therefore propose a prospective randomized controlled trial on the use of this device in adult LT and see whether its use could reduce neurological mishaps.

Details

Lead sponsor	The University of Hong Kong
Phase	NA
Status	UNKNOWN
Enrolment	158
Start date	Mon Jul 30 2018 00:00:00 GMT+0000 (Coordinated Universal Time)
Completion	Sun May 31 2020 00:00:00 GMT+0000 (Coordinated Universal Time)

Conditions

• Liver Failure

Interventions

• Cerebral oximeter

Countries

China, Hong Kong