NCT04121533: VitD-OA

Vitamin D Supplementation in Knee Osteoarthritis

Completed NA Last updated 10 October 2019

What this trial tests

NA trial testing Placebo in Osteoarthritis, Knee in 73 participants. Completed in 8 January 2013.

Timeline

28 July 2011

Primary endpoint
8 January 2013

8 January 2013

Quick facts

Lead sponsor	Intermountain Health Care, Inc.
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	treatment
Enrollment	73
Start date	28 July 2011
Primary completion	8 January 2013
Estimated completion	8 January 2013

Drugs / interventions tested

• Placebo
• Vitamin D (cholecalciferol)
• Glucosamine sulfate and omega-3 fatty acids

Conditions studied

• Osteoarthritis, Knee — all drugs for Osteoarthritis, Knee →
• Vitamin D Supplementation — all drugs for Vitamin D Supplementation →

Sponsor

Intermountain Health Care, Inc. — full company profile →

Who can join

Adults 18 to 60, any sex, with Osteoarthritis, Knee or Vitamin D Supplementation. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Muscular (i.e., quadriceps) weakness is a major risk factor for predisposing the knee to osteoarthritis, impairing physical function, and increasing patient-reported pain. Muscular weakness is a consequence of and could contribute to the development of knee osteoarthritis. Minimizing muscular weakness has been fount to improve activities of daily living in patients with osteoarthritis symptoms. Although vitamin D associates with muscular strength in young and old populations, it is unknown if vitamin D supplementation improves muscular strength in subjects with osteoarthritis or osteoarthritis symptoms. It is also unknown if supplemental vitamin D alters circulating cytokine concentrations in subjects with knee osteoarthritis. Furthermore, it is probable that a more comprehensive supplement is necessary to improve muscular strength. Such as glucosamine sulfate and omega-3 fatty acids (i.e., eicosapentaenoic and docosahexaenoic acids) which could be influential on knee pain and inflammation as well as muscular strength. Therefore, the purpose of this study is to identify the influence of vitamin D supplementation with and without glucosamine sulfate and omega-3 fatty acids on circulating cytokine concentrations and muscular strength in subjects with knee osteoarthritis symptoms. This study is intended to establish preliminary data identifying the influence of vitamin D supplementation on circulating cytokines and muscular strength in subjects with osteoarthritis at no more than minimal risk exposure to subjects.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Omega-3 Fatty Acids for the Management of Osteoarthritis: A Narrative Review.
   Cordingley DM, Cornish SM. · · 2022 · cited 25× · PMID 36014868 · DOI 10.3390/nu14163362