Who is sponsoring NCT04121338?

NCT04121338 is sponsored by Johns Hopkins University.

What condition does NCT04121338 study?

NCT04121338 studies Dysautonomia.

What drugs are being tested in NCT04121338?

Interventions: Celiac ganglion block, Liposomal bupivacaine.

What is the status of NCT04121338?

NCT04121338 is currently COMPLETED.

Last reviewed 2021-05-19 · How we verify

Temporary Celiac Ganglion Block as a Test Before Celiac Ganglion Resection for Dysautonomia-Related Bowel Dysmotility

NCT04121338 PHASE1 COMPLETED

Dysautonomia is malfunction of the autonomic nervous system. It usually results from overactivity of the sympathetic portion and over-secretion of acetylcholine. Symptoms depend on the organ involved by this sympathetic overstimulation. Involvement of the gastrointestinal system results in chronic dysmotility, nausea, vomiting, food intolerance, weight loss and need for feeding tube placement and/or parenteral feeding. Autonomic celiac ganglia resection has been shown to alleviate symptoms as it interrupts the sympathetic stimulation to the gastrointestinal (GI) system, however there is no pre surgery test to confirm the diagnosis. The investigators' objective is to temporarily block the celiac ganglion with a long acting anesthetic (liposomal bupivacaine). If symptoms abate the diagnosis is confirmed and patient will proceed to surgery.

Details

Lead sponsor	Johns Hopkins University
Phase	PHASE1
Status	COMPLETED
Enrolment	15
Start date	Mon Dec 09 2019 00:00:00 GMT+0000 (Coordinated Universal Time)
Completion	Sat May 15 2021 00:00:00 GMT+0000 (Coordinated Universal Time)

Conditions

Dysautonomia

Interventions

Celiac ganglion block
Liposomal bupivacaine

Countries

United States