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Effective Mechanisms of Wu-Chu-Yu Tang on Gastroesophageal Disorder
Gastroesophageal reflux disorder (GERD) is due to gastric content reflux to esophagus cause symptom and complication including intra-esophagus such as reflux esophagitis, and extra-esophagus such as cough etc. Because the changes of dietary habit, and improvement of examination skill and data analysis, the prevalence of GERD increased 2.5 multiple from 1995 to 2002, and suggesting the prevalence is 25% in Taiwan community. The etiology of GERD is multi-effect, such as transient lower esophageal sphincter relaxation and abnormal pressure of lower esophageal sphincter, which may induced the esophageal mucosal injury by gastric acid, bile or pancreases enzyme. Wu-Chu-Yu tang consists of Evodia fargesii Dode (Evodia Fruit), Panax ginseng C. (Ginseng), Ziziphus jujube Mill (Chinses Date), Zingiber officinale Rosee (Fresh Ginger).According to "I-Fang-Chi-Chieh" and "Shanghonzobinglun" recordings that Wu-Chu-Yu tang can treat vomiting, and also can relax gastric tonicity and can enhance peristalsis of stomach. According to Randomized, double blind, placebo control trial to evaluate the efficacy of Wu-Chu-Yu Tang on gastroesophageal reflux disease, we know the Wu-Chu-Yu tang have the equivalent effect proton pump inhibitor omeprazole. But, the mechanism of Wu-Chu-Yu tang is still unknown.
Details
| Lead sponsor | China Medical University Hospital |
|---|---|
| Phase | Phase 4 |
| Status | UNKNOWN |
| Enrolment | 55 |
| Start date | 2019-10 |
| Completion | 2021-09 |
Conditions
- Wu-Chu-Yu Tang
- Gastroesophageal Reflux Disorder
- 24 Hours Esophageal PH and Multichannel Intraluminal Impedance Testing
Interventions
- Wu-Chu-Yu tang
Primary outcomes
- 24 hours esophageal PH — 28 days
Analysis the 24 hours PH change - DeMeester score — 28 days
DeMeester score had two major component as 1.total time of pH\<4(%) and 2.number of reflux episode. Each major part had two minor component.Fist one, percentage of total time pH\<4, had 1. percentage of upright time when pH\<4 and 2.percentage of supine time when pH\<4. Secondary part, number of reflux episode, had 1.number of reflux episode over 5 mintues and 2.longest reflux time. Finally, there was a composite score as the DeMeester score.
Countries
Taiwan