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NCT04118348

Evaluating the Efficacy of Pediatric Lipid Screening Alerts

Completed NA Results posted Last updated 7 November 2023
What this trial tests

NA trial testing Best Practice Alert in Hypercholesterolemia in 13,340 participants. Completed in 11 October 2020.

Timeline
10 October 2019
Primary endpoint
11 October 2020
11 October 2020

Quick facts

Lead sponsorGeisinger Clinic
PhaseNA
StatusCompleted
Study typeINTERVENTIONAL
Allocationrandomized
Designfactorial
Maskingdouble
Primary purposescreening
Enrollment13,340
Start date10 October 2019
Primary completion11 October 2020
Estimated completion11 October 2020
Sites1 location across United States

Drugs / interventions tested

Conditions studied

Sponsor

Geisinger Clinic

Who can join

Adults 9 to 11, any sex, with Hypercholesterolemia or Hypercholesterolemia, Familial. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Lipid Panel Order Primary · 1 day

Provider ordered a lipid panel to an eligible patient during the patient's first visit within the study period (binary variable).

GroupValue95% CI
Passive Control156
Best Practice Alert (BPA-only)454
Health Maintenance Topic (HMT-only)236
BPA+HMT494
Lipid Panel Screening Primary · 1 week

Patient completed a lipid panel screening within seven days of the patient's first visit (binary variable). This screening is not linked to any order made at the patient's first visit (i.e., Outcome Measure 1).

GroupValue95% CI
Passive Control47
Best Practice Alert (BPA-only)98
Health Maintenance Topic (HMT-only)70
BPA+HMT120

Sponsor's own description

The purpose of the study is to evaluate prospectively the impact of different system alerts on the prescription of lipid panels to pediatric Geisinger patients (9-11 years old), as per the now-universal guidelines. This will help quantify the relative effectiveness of different alerts and combinations of alerts on provider prescribing behavior and patient uptake of screening.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

  1. Comparison of Clinical Decision Support Tools to Improve Pediatric Lipid Screening.
    Goren A, Santos HC, Davis TW, Lowe RB, et al · · 2024 · cited 3× · PMID 38401785 · DOI 10.1016/j.jpeds.2024.113973

Verify or expand the search:

Other trials of Best Practice Alert

Trials testing the same drug.

Other recruiting trials for Hypercholesterolemia

Currently open trials in the same condition.

Other Geisinger Clinic trials

Trials by the same sponsor.

Verify against primary sources

Data sources for this page

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04118348.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing