NCT04117490 is a NA clinical trial of Epiitalis in Knee Osteoarthritis, sponsored by Vedic Lifesciences Pvt. Ltd..

Who is sponsoring NCT04117490?

NCT04117490 is sponsored by Vedic Lifesciences Pvt. Ltd..

What drugs are being tested in NCT04117490?

Interventions in NCT04117490: Epiitalis, Placebo.

What condition does NCT04117490 study?

NCT04117490 studies Knee Osteoarthritis.

Is NCT04117490 still recruiting?

NCT04117490 is currently completed. Last updated 1 February 2022.

Last reviewed 2022-02-01 · How we verify

NCT04117490

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

To Assess Efficacy of Epiitalis on Knee Pain in Patients Suffering From Knee Osteoarthritis

Completed NA Last updated 1 February 2022

What this trial tests

NA trial testing Epiitalis in Knee Osteoarthritis in 237 participants. Completed in 21 October 2020.

Timeline

12 December 2019

Primary endpoint
21 October 2020

21 October 2020

Quick facts

Lead sponsor	Vedic Lifesciences Pvt. Ltd.
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	other
Enrollment	237
Start date	12 December 2019
Primary completion	21 October 2020
Estimated completion	21 October 2020
Sites	8 locations across India

Drugs / interventions tested

Epiitalis
Placebo

Conditions studied

Knee Osteoarthritis — all drugs for Knee Osteoarthritis →

Sponsor

Vedic Lifesciences Pvt. Ltd. — full company profile →

Who can join

Adults 40 to 65, any sex, with Knee Osteoarthritis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Epiitalis is an ingredient of a currently marketed product named as Osteo-Restore, indicated for joint health.The present study is primarily planned to establish the role of Epiitalis as a single ingredient in the treatment of mild to moderate cases of knee Osteoarthritis.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

The Biota orientalis, oil extract Epiitalis<sup>®</sup>, is efficacious at reducing the symptoms of knee osteoarthritis: a pilot, multi-site, dose-ranging, randomized, blinded, placebo-controlled trial.
Mitchell PG, Bright CA, Bright DR, Srivastava SN, et al · · 2022 · cited 1× · PMID 35732989 · DOI 10.1007/s10787-022-01013-y
The Biota Orientalis Oil Extract, Epiitalis®, Is Efficacious At Reducing The Symptoms Of Knee Osteoarthritis: A Pilot, Multi-Site, Dose-Ranging, Randomized, Blinded, Placebo-Controlled Trial
Mitchell PG, Bright C, Bright D, Srivast S, et al · · 2022 · DOI 10.21203/rs.3.rs-1451790/v1

Verify or expand the search:

Other recruiting trials for Knee Osteoarthritis

Currently open trials in the same condition.

NCT06906939 — A Randomized Pilot rTMS Trial for Knee Arthritis Pain and Depression · EARLY_PHASE1 · recruiting
NCT05823727 — Effects of Collagen Peptide Supplementation on Connective Tissue Remodeling, Functional Outcomes, and Wound Healing Afte · NA · recruiting
NCT07370480 — Knee Osteoarthritis and Thermal Spa Treatment · NA · recruiting
NCT07507175 — Gastrocnemius Myofascial Release in Females With Knee Osteoarthritis · NA · recruiting
NCT07386600 — Dexamethasone vs Dexmedetomidine for iPACK + ACB in TKA · NA · recruiting

Other Vedic Lifesciences Pvt. Ltd. trials

Trials by the same sponsor.

NCT07141368 — Single Oral Dose Comparative Bioavailability Study of Investigational Product in Healthy Human Subjects Under Fasting Co · NA · not yet recruiting
NCT07033754 — A Study to Assess the Effect Probiotic Supplement on Immune Health in Teachers Prone to Upper Respiratory Tract Infectio · NA · not yet recruiting
NCT06917287 — A Clinical Study to Evaluate the Efficacy of Native CT-II® in Individuals With Knee Osteoarthritis · NA · recruiting
NCT06859346 — A Clinical Study to Assess the Effect of Tisina Complex on Cognitive Health in Individuals With Mild Cognitive Impairmen · NA · completed
NCT06473246 — A Study to Determine Safety, Pharmakokinetics and Efficacy of the Different Doses of VL-SE-01 in Healthy Participants. · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04117490 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Vedic Lifesciences Pvt. Ltd.
Last refreshed: 1 February 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04117490.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing