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NCT04117321
Mother-infant Microbiota Transmission and Its Link to the Health of the Baby
trial in Gut Microbiome in 20,000 participants. Currently enrolling.
2 October 2026
Quick facts
| Lead sponsor | Chinese University of Hong Kong |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 20,000 |
| Start date | 23 September 2019 |
| Primary completion | 2 October 2026 |
| Estimated completion | 2 October 2027 |
| Sites | 1 location across China |
Conditions studied
- Gut Microbiome — all drugs for Gut Microbiome →
- Mother to Child Transmission — all drugs for Mother to Child Transmission →
Sponsor
Chinese University of Hong Kong
Who can join
Eligibility, any sex, with Gut Microbiome or Mother to Child Transmission. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The human intestinal tract harbors a diverse and complex microbial community, known as gut microbiota, which is critical in sustaining physiology, metabolism, nutrition and immune function. Dysbiosis of gut microbiota has been linked with obesity, hyperglycemia, hyperlipidemia, inflammatory bowel disease and other chronic inflammatory diseases. Gut microbiota is affected by host genetic markup, diet and life style; and therefore varied by human races and geographical locations. The development of gut microbiota starts before birth. The infant's microbiome can impact on human health in later life. The microbiome of pregnant women are associated with early-life microbiota of their offspring as well as growth, neurodevelopment and the development of allergic and neurocognitive disorders. Early childhood, when the microbiota is less mature and more malleable, is a golden age for microbiota manipulation to prevent disease. Studying microbiota at this golden age also allow us to dissect the development of a faulty microbiota and identify therapeutic targets to reverse it and cure diseases that are already developed.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
MOMMY study profile: An integrative early-life multi-omics cohort in China.
Zhang L, Liu Y, Wang S, Ching JY, et al · · 2025 · PMID 41676450 · DOI 10.1002/imo2.70068
Verify or expand the search:
- PubMed search for NCT04117321
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04117321 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Chinese University of Hong Kong
- Last refreshed: 29 May 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04117321.
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