NCT04117061 (OPTIMA) is a NA clinical trial of Observation in Acute Appendicitis, sponsored by Vilnius University.

Who is sponsoring NCT04117061?

NCT04117061 is sponsored by Vilnius University.

What drugs are being tested in NCT04117061?

Interventions in NCT04117061: Observation.

What condition does NCT04117061 study?

NCT04117061 studies Acute Appendicitis.

Is NCT04117061 still recruiting?

NCT04117061 is currently status unknown. Last updated 7 October 2019.

Last reviewed 2019-10-07 · How we verify

NCT04117061: OPTIMA

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Optimizing the Diagnosis of Acute Appendicitis

Status unknown NA Last updated 7 October 2019

What this trial tests

NA trial testing Observation in Acute Appendicitis in 200 participants. Status unknown.

Timeline

1 December 2018

Primary endpoint
1 January 2021

1 May 2021

Quick facts

Lead sponsor	Vilnius University
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	diagnostic
Enrollment	200
Start date	1 December 2018
Primary completion	1 January 2021
Estimated completion	1 May 2021
Sites	1 location across Lithuania

Drugs / interventions tested

Observation

Conditions studied

Acute Appendicitis — all drugs for Acute Appendicitis →

Sponsor

Vilnius University

Who can join

18 and older, any sex, with Acute Appendicitis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Aim of the study: to identify the signs of acute appendicitis delta signs - clinical, laboratory or ultrasound signs, whose change (delta) would allow to identify or deny the diagnosis of acute appendicitis without a computed tomography examination and thus to lower computed tomography rates.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Observation Safely Reduces the Use of the Computerized Tomography in Medium-to-Low-Risk Patients with Suspected Acute Appendicitis: Results of a Randomized Controlled Trial.
Luksaite-Lukste R, Gecaite I, Marcinkeviciute K, Dumskis E, et al · · 2024 · cited 2× · PMID 38929896 · DOI 10.3390/jcm13123363
ECR 2022 Book of Abstracts.
· 2022 · cited 2× · PMID 36585546 · DOI 10.1186/s13244-022-01337-x

Verify or expand the search:

Other trials of Observation

Trials testing the same drug.

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NCT07563088 — SPARE-1st: Surgery Alone vs Surgery Plus Postoperative Radiotherapy for Sinonasal Adenoid Cystic Carcinoma · not yet recruiting
NCT07513324 — Risk-adapted Therapy in HPV-positive Oropharyngeal Cancer Using Circulating Tumor (ct) HPV DNA Profiling (ReACT 2.0) · Phase 2 · not yet recruiting
NCT07457099 — Impact of Postoperative Radiotherapy Versus PD-1 Inhibitor Maintenance on Survival in Resectable Locally Advanced Oral a · not yet recruiting
NCT07472478 — Phase II Neoadjuvant Study of Garsorasib Followed by Ivonescimab Plus Chemotherapy in Resectable Stage IIA-IIIB KRAS G12 · Phase 2 · not yet recruiting

Other recruiting trials for Acute Appendicitis

Currently open trials in the same condition.

NCT07496723 — Comparison of Diagnostic Methods in Patients Operated for Suspected Appendicitis · recruiting
NCT07008092 — Prostaglandin-E Urinary Metabolite (PGE-M) as a Predictor of Acute Appendicitis in Children · recruiting
NCT07492329 — Antibiotics vs Surgery in Acute Appendicitis · NA · active not recruiting
NCT06563349 — Magnesium Sulfate in Children Undergoing Laparoscopic Appendectomy · Phase 4 · recruiting
NCT03236961 — Optimizing the Antibiotic Treatment of Uncomplicated Acute Appendicitis · NA · active not recruiting

Other Vilnius University trials

Trials by the same sponsor.

NCT06966752 — Comparison of Continuous Positive Airway Pressure (CPAP) and Non-Invasive Positive Pressure Ventilation (NIPPV) in Prete · NA · recruiting
NCT07024901 — The Effects of the Somatic Intervention 'Dance-Walk' on Body Awareness, Vitality, and Mental Health in Help-Seeking Adul · NA · completed
NCT06651411 — The Feasibility of Chatbot-based Stress Management Intervention STARS for Youth in Lithuania · NA · active not recruiting
NCT06475716 — Guided Internet-based Trauma-focused CBT Programme for Post-traumatic Stress Disorder 'Spring' · NA · not yet recruiting
NCT06502704 — Bile Acids and Microbiome in Early Colorectal Carcinogenesis · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04117061 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Vilnius University
Last refreshed: 7 October 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04117061.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing