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NCT04116242
MERTK Signalling in Monocytes/Macrophages in Patients With Liver Disease
trial testing blood sampling for research purpose in Liver Disease in 277 participants. Completed in 10 June 2024.
10 June 2024
Quick facts
| Lead sponsor | University Hospital, Basel, Switzerland |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 277 |
| Start date | 27 August 2015 |
| Primary completion | 10 June 2024 |
| Estimated completion | 10 June 2024 |
| Sites | 4 locations across United Kingdom, Switzerland |
Drugs / interventions tested
- blood sampling for research purpose
- clinical data collection
- Health-related Questionnaires
- Sampling other biological materials (e.g. liver biopsies, liver resections, ascites, urine, gut biopsies)
Conditions studied
- Liver Disease — all drugs for Liver Disease →
- Cirrhosis of the Liver — all drugs for Cirrhosis of the Liver →
- Acute-On-Chronic Liver Failure — all drugs for Acute-On-Chronic Liver Failure →
- Liver Failure — all drugs for Liver Failure →
Sponsor
University Hospital, Basel, Switzerland
Who can join
18 and older, any sex, with Liver Disease or Cirrhosis of the Liver. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study is to investigate MER receptor tyrosine kinase (MERTK) signalling cascade on monocytes and tissue macrophages in respect to innate immune function of the cells in patients with cirrhosis at different stages of disease (Child A, B, C, acute decompensation, acute-on-chronic liver failure (ACLF)) and in comparison to patients with acute liver failure and to healthy controls.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Expression of AXL receptor tyrosine kinase relates to monocyte dysfunction and severity of cirrhosis.
Brenig R, Pop OT, Triantafyllou E, Geng A, et al · · 2020 · cited 34× · PMID 31822557 · DOI 10.26508/lsa.201900465 -
AXL Expression on Homeostatic Resident Liver Macrophages Is Reduced in Cirrhosis Following GAS6 Production by Hepatic Stellate Cells.
Pop OT, Geng A, Flint E, Singanayagam A, et al · · 2023 · cited 15× · PMID 37004869 · DOI 10.1016/j.jcmgh.2023.03.007
Verify or expand the search:
- PubMed search for NCT04116242
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Currently open trials in the same condition.
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Other University Hospital, Basel, Switzerland trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04116242 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Hospital, Basel, Switzerland
- Last refreshed: 25 June 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04116242.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing