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NCT04114578
Exploratory Observational Prospective Study in Neonatal and Pediatric Congenital Diaphragmatic Hernia
trial testing Echocardiography in Congenital Diaphragmatic Hernia in 80 participants. Currently enrolling.
31 December 2023
Quick facts
| Lead sponsor | McGill University Health Centre/Research Institute of the McGill University Health Centre |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 80 |
| Start date | 1 October 2019 |
| Primary completion | 31 December 2023 |
| Estimated completion | 30 June 2025 |
| Sites | 1 location across Canada |
Drugs / interventions tested
- Echocardiography
Conditions studied
- Congenital Diaphragmatic Hernia — all drugs for Congenital Diaphragmatic Hernia →
Sponsor
McGill University Health Centre/Research Institute of the McGill University Health Centre
Who can join
Under 17, any sex, with Congenital Diaphragmatic Hernia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
CDH is associated with lung hypoplasia, pulmonary hypertension, and left ventricular hypoplasia. Use of new STE techniques (heart ultrasound) showed that CDH newborns have decreased LV size and function, potentially explaining the non-response to iNO, and that these cardiac findings were associated with poor outcomes. Our hypothesis: CDH newborns persist to have some degree of LV hypoplasia in the pediatric and adolescent life and pulmonary pressures remain increased during growth. Patients with decreased cardiac performance by STE and/or with PH have higher concomitant neonatal or pediatric morbidities and altered neurodevelopmental profile
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT04114578
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other recruiting trials for Congenital Diaphragmatic Hernia
Currently open trials in the same condition.
- NCT05213676 — De-implementing Inhaled Nitric Oxide for Congenital Diaphragmatic Hernia · Phase 4 · recruiting
- NCT07187206 — Safety and Efficacy of FETO in CDH Phase III · Phase 3 · recruiting
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- NCT03138863 — Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia (FETO) · NA · recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04114578 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by McGill University Health Centre/Research Institute of the McGill University Health Centre
- Last refreshed: 22 November 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04114578.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing