NCT04107545 (WAVE) is a NA clinical trial of athletes in Athletes, sponsored by University Hospital, Clermont-Ferrand.

Who is sponsoring NCT04107545?

NCT04107545 is sponsored by University Hospital, Clermont-Ferrand.

What drugs are being tested in NCT04107545?

Interventions in NCT04107545: athletes.

Is NCT04107545 still recruiting?

NCT04107545 is currently completed. Last updated 8 March 2024.

Last reviewed 2024-03-08 · How we verify

NCT04107545: WAVE

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Metabolic, Functional and Nutritional Responses to Weight Cycling in Athletes: The WAVE Study

Completed NA Last updated 8 March 2024

What this trial tests

NA trial testing athletes in Athletes in 48 participants. Completed in 12 December 2023.

Timeline

3 May 2021

Primary endpoint
12 December 2023

12 December 2023

Quick facts

Lead sponsor	University Hospital, Clermont-Ferrand
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	other
Enrollment	48
Start date	3 May 2021
Primary completion	12 December 2023
Estimated completion	12 December 2023
Sites	1 location across France

Drugs / interventions tested

athletes

Conditions studied

Athletes — all drugs for Athletes →

Sponsor

University Hospital, Clermont-Ferrand

Who can join

Adults 18 to 35, any sex, with Athletes. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Many elite athletes are submitted to frequent rapid weight loss periods to meet their competition weight category and then experience weight cycling (lowing and gaining weight regularly). This weight cycling induce severe temporary energetic and metabolic changes and when repeated over time can lead to permanent metabolic adaptations that might favor metabolic disorders, body weight gain and body composition changes (favoring fat mass). The exact effects of this weight cycling are not clear yet, especially in terms of metabolic, energetics, nutritional functional and psychological impacts. Better understand these adaptations and their variations during weight loss and weight gain in regular weight cycler is of main importance to prevent these athletes for future health issues. The aim of the present project if to assess these metabolic, functional, energetic and nutritional adaptations during weight loss, weight stable and weight gain periods in athletes experiencing regular weight cycling.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

The habitual degree of weight loss might be associated with specific fat and protein intakes during a period of weight maintenance in athletes used to weight variations: preliminary results from the WAVE study.
Bagot S, Pereira B, Miles-Chan J, Gryson C, et al · · 2024 · cited 1× · PMID 39178640 · DOI 10.1016/j.nutres.2024.07.009
The type of sport, but not sex, impacts body composition and metabolic response to a complete weight loss-weight regain episode in weight cycling athletes: results from the WAVE study.
Bagot S, Ramos I, Miles-Chan J, Dulloo A, et al · · 2025 · PMID 39919268 · DOI 10.1139/apnm-2024-0376

Verify or expand the search:

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04107545 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University Hospital, Clermont-Ferrand
Last refreshed: 8 March 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04107545.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing