NCT04107363

Oropharyngeal Aspiration to Reduce Ventilator-Related Pneumonia

Completed NA Last updated 27 September 2019

What this trial tests

NA trial testing Oropharyngeal aspiration before changing the position of the patient in Ventilator-associated Bacterial Pneumonia in 40 participants. Completed in 30 June 2019.

Timeline

1 July 2015

Primary endpoint
30 April 2019

30 June 2019

Quick facts

Lead sponsor	Ayşe AKBIYIK
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	none
Primary purpose	prevention
Enrollment	40
Start date	1 July 2015
Primary completion	30 April 2019
Estimated completion	30 June 2019

Drugs / interventions tested

• Oropharyngeal aspiration before changing the position of the patient
• Control group:

Conditions studied

• Ventilator-associated Bacterial Pneumonia — all drugs for Ventilator-associated Bacterial Pneumonia →

Sponsor

Ayşe AKBIYIK

Who can join

18 and older, any sex, with Ventilator-associated Bacterial Pneumonia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Ventilator-associated pneumonia (VAP) is one of the healthcare-related infections that is common in critically ill patients, prolongs hospital stay, significantly increases mortality and additional health care costs.

Microaspiration of oropharyngeal secretions the primary pathway in the formation of VAP has led researchers to focus on the detection of applications to prevent microbial colonization. Continuous or intermittent oropharyngeal aspiration, open system aspiration versus closed system aspiration, extensive oral care, oropharyngeal aspiration prior to patient positioning are some of these applications.

When the patient is turned to position, the outbreak accumulated in the oral cavity is more likely to move to the lower respiratory tract. In this study, it is assumed that aspiration of oropharyngeal secretions prior to each position change will reduce the accumulation of oral secretion in the endotracheal tube cuff and reduce aspiration of contaminated secretion and reduce the risk of developing VIP. This randomized controlled experimental study was planned to confirm the validity of this assumption.

This study was a randomized controlled experimental study designed to investigate the effect of oropharyngeal aspiration on decreasing the incidence of ventilator-associated pneumonia in patients receiving mechanical ventilation. The research was conducted between July 2015 and April 2019 in anesthesiology and reanimation intensive care unit. The study was carried out with 20 patients who underwent oropharyngeal aspiration as needed and 20 patients with oropharyngeal aspiration prior to each change of position.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. The effect of oropharyngeal aspiration before position change on reducing the incidence of ventilator- associated pneumonia.
   Akbiyik A, Hepçivici Z, Eşer I, Uyar M, et al · · 2021 · cited 6× · PMID 33230628 · DOI 10.1007/s10096-019-03789-4