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NCT04106752
Timing of Meal and Caffeine Intake on Substrate Use and Exercise Efficiency
NA trial testing Caffeine in Healthy in 8 participants. Completed in 29 July 2019.
30 June 2019
Quick facts
| Lead sponsor | American University of Beirut Medical Center |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | single |
| Primary purpose | other |
| Enrollment | 8 |
| Start date | 5 March 2018 |
| Primary completion | 30 June 2019 |
| Estimated completion | 29 July 2019 |
| Sites | 1 location across Lebanon |
Drugs / interventions tested
- Caffeine (caffeine) — full drug profile →
Conditions studied
- Healthy — all drugs for Healthy →
Sponsor
American University of Beirut Medical Center
Who can join
Adults 18 to 30, any sex, with Healthy. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
During the past decades, considerable emphasis has been directed to analyzing the potential role of caffeine on substrate use and exercise performance. Research shows that caffeine ingestion prior to exercise has beneficial effects on submaximal exercise capacity and time trial protocols. This effect is mediated by an increase in plasma free fatty acids and intramuscular triglyceride utilization, preserving muscle and liver glycogen. Generally, a dose between 4 - 9 mg/kg body mass is administered to athletes in order to observe a positive or ergogenic effect. Caffeine ingestion (6 mg/kg) improved exercise performance in a long duration protocol (2 hours + \~ 30 min time trial) regardless of the administration time (1 hour before or during exercise). Lower doses of caffeine (\~ 1.5 mg/kg), when added to a carbohydrate solution increased exercise performance in a similar fashion. In rats, caffeine has been shown to have a biphasic action on postprandial glucose metabolism. When ingested before a meal, hepatic glycogenesis is blunted. Its ingestion during and after a meal allows glycogenesis to occur. Manipulating meal and caffeine timing before low intensity exercise, comparable to every-day life activities, is of great interest in assessing substrate use and muscular efficiency. it would be also interesting to see how this meal or caffeine timing manipulation influence the energetics of different phenotypes.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT04106752
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Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04106752 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by American University of Beirut Medical Center
- Last refreshed: 27 September 2019
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